Show simple item record

dc.contributor.authorLiu, Jun
dc.contributor.authorYu, Cheng
dc.contributor.authorLu, Gonggong
dc.contributor.authorTang, James Zhenggui
dc.contributor.authorWang, Yonghui
dc.contributor.authorZhang, Boqing
dc.contributor.authorSun, Yong
dc.contributor.authorLin, Hai
dc.contributor.authorWang, Qiguang
dc.contributor.authorLiang, Jie
dc.contributor.authorFan, Yujiang
dc.contributor.authorZhang, Xingdong
dc.date.accessioned2019-01-10T10:52:48Z
dc.date.available2019-01-10T10:52:48Z
dc.date.issued2018-12-12
dc.identifier.citationLiu, J. (2018) 'Bionic cartilage acellular matrix microspheres as scaffold for engineering cartilage', Journal of Materials Chemistry B. 7(4) doi: 10.1039/C8TB02999Gen
dc.identifier.issn2050-750Xen
dc.identifier.doi10.1039/C8TB02999G
dc.identifier.urihttp://hdl.handle.net/2436/622031
dc.description.abstractExtracellular matrix (ECM) scaffolds made from decellularized natural cartilage have been successfully used in cartilage lesion repair, but allogeneic cartilage donors are always in shortage and xenogeneic cartilage tissues may have the risk of unknown disease transfer. In this study, we constructed artificial bionic cartilage microspheres by encapsulating MSCs in collagen microspheres and cultured in a chondrogenic-inducing medium. Then, acellular matrix microsphere (BCAMM) scaffolds were fabricated from the cultured microspheres at three different developmental stages. A novel technique was introduced to fabricate BCAMM scaffolds, which enabled the production and utilization of the scaffolds in a short time. Due to the differences in surface morphologies and biological compositions, the three BCAMM scaffolds showed different chondrogenic effects. The 10-day BCAMM (10-BCAMM) scaffold showed the best overall results, successfully inducing MSC chondrogenesis without any additional fetal bovine serum or induction components (TGF-β or dexamethasone). In comparison, the 5-day BCAMM (5-BCAMM) scaffold showed potential osteogenic effects. The advantages of micron-sized BCAMMs are outlined, specifically in the easier decellularization process without grinding, homogeneous cell seeding and infiltration, chondrogenic induction and better fitting to the irregular lesion shape.en
dc.formatapplication/PDFen
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.urlhttps://pubs.rsc.org/en/Content/ArticleLanding/2018/TB/C8TB02999G#!divAbstracten
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectnatural cartilageen
dc.subjectextracellular matrix scaffoldsen
dc.subjectmesenchymal stem cellsen
dc.subjectin vito chrondrogensisen
dc.titleBionic cartilage acellular matrix microspheres as scaffold for engineering cartilageen
dc.typeJournal article
dc.identifier.journalJournal of Materials Chemistry Ben
dc.date.accepted2018-12-12
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW100119JZTen
rioxxterms.versionAMen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-01-10en
dc.source.volume7
dc.source.issue4
dc.source.beginpage640
dc.source.endpage650
refterms.dateFCD2019-01-10T10:52:49Z
refterms.versionFCDAM


Files in this item

Thumbnail
Name:
Bionic cartilage acellular ...
Embargo:
2019-12-12
Size:
1.587Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States