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dc.contributor.authorLiang, Yaping
dc.contributor.authorXu, Xiaojia
dc.contributor.authorYin, Mingjuan
dc.contributor.authorZhang, Yan
dc.contributor.authorHuang, Lingfeng
dc.contributor.authorChen, Ruoling
dc.contributor.authorNi, Jindong
dc.date.accessioned2018-12-13T14:08:15Z
dc.date.available2018-12-13T14:08:15Z
dc.date.issued2018-11-03
dc.identifier.citationLiang, Y. et al (2018) Effects of Berberine on Blood Glucose in Patients with Type 2 Diabetes Mellitus: A Systematic Literature Review and A Meta-analysis, Endocrine Journal. DOI: 10.1507/endocrj.EJ18-0109en_US
dc.identifier.issn0918-8959en_US
dc.identifier.doi10.1507/endocrj.EJ18-0109
dc.identifier.urihttp://hdl.handle.net/2436/621980
dc.description.abstractWe conducted a systematic review and meta-analysis to evaluate the effect of Berberine on glucose in patients with type 2 diabetes mellitus and identify potential factors may modifying the hypoglycemic effect. We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database to identify randomized controlled trials that investigated the effect of Berberine. We calculated weighted mean differences (WMD) and 95% confidence interval (CI) for fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and glycated haemoglobin (HbA1c) levels. Twenty-eight studies were identified for analysis, with a total of 2,313 type 2 diabetes mellitus (T2DM) patients. The pool data showed that Berberine treatment was associated with a better reduction on FPG (WMD = –0.54 mmol/L, 95% CI: –0.77 to –0.30), PPG (WMD = –0.94 mmol/L, 95% CI: –1.27 to –0.61), and HbA1c (WMD = –0.54 mmol/L, 95% CI: –0.93 to –‍0.15) than control groups. Subgroup-analyses indicated that effects of Berberine on blood glucose became unremarkable as the treatment lasted more than 90 days, the daily dosage more than 2 g/d and patients aged more than 60 years. The efficiency of Berberine combined with hypoglycaemics is better than either Berberine or hypoglycaemic alone. The dosage and treatment duration of Berberine and patients’ age may modify the effect.en_US
dc.formatapplication/PDFen_US
dc.language.isoenen_US
dc.publisherThe Japan Endocrine Societyen_US
dc.relation.urlhttps://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ18-0109/_articleen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectberberineen_US
dc.subjectblood glucoseen_US
dc.subjectdiabetes mellitusen_US
dc.subjectrandomised clinical trialsen_US
dc.subjectmeta-analysisen_US
dc.titleEffects of berberine on blood glucose in patients with type 2 diabetes mellitus: A systematic literature review and a meta-analysisen_US
dc.typeJournal article
dc.identifier.journalEndocrine Journalen_US
dc.date.accepted2018-10-04
rioxxterms.funderUniversity of Wolverhamptonen_US
rioxxterms.identifier.projectUOW131218RCen_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2019-11-03en_US
dc.source.volume66
dc.source.issue1
dc.source.beginpage51
dc.source.endpage63
refterms.dateFCD2018-12-13T14:08:16Z
refterms.versionFCDAM
refterms.dateFOA2019-03-08T05:32:07Z


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