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dc.contributor.authorYoung, M. Rita I.
dc.contributor.authorNeville, Brad W.
dc.contributor.authorChi, Angela C.
dc.contributor.authorLathers, Deanne M. R.
dc.contributor.authorGillespie, M. Boyd
dc.contributor.authorDay, Terry A.
dc.date.accessioned2018-10-24T15:41:12Z
dc.date.available2018-10-24T15:41:12Z
dc.date.issued2007-03-17
dc.identifier.citationAutocrine motility-stimulatory pathways of oral premalignant lesion cells 2007, 24 (2):131 Clinical & Experimental Metastasisen_US
dc.identifier.doi10.1007/s10585-007-9063-0
dc.identifier.urihttp://hdl.handle.net/2436/621809
dc.description.abstractPatients with premalignant oral lesions have varying levels of risk of developing oral squamous cell carcinoma (OSCC), whose aggressiveness requires increased motility. Not known is if and how premalignant oral lesion cells acquire the increased motility characteristic of OSCC. This was addressed by immunohistochemical analysis of banked premalignant lesion tissues and by functional analyses using cultures established from premalignant oral lesions and OSCC. These studies showed premalignant oral lesion cells and OSCC to be more motile than normal keratinocytes. Concomitantly, levels of ceramide were reduced. The activity of the protein phosphatase PP-2A, which restricts motility and which can be activated by ceramide, was also diminished. This was due to IL-10 released from premalignant lesion cells. Treatment with a membrane-permeable ceramide restored PP-2A activity and blocked migration. These studies show an autocrine motility-stimulatory pathway that is mediated in premalignant lesion cells by IL-10 through its reduction of ceramide levels and inhibition of PP-2A activity.en_US
dc.formatapplication/PDFen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.urlhttp://link.springer.com/10.1007/s10585-007-9063-0en_US
dc.rightsArchived with thanks to Clinical & Experimental Metastasisen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleAutocrine motility-stimulatory pathways of oral premalignant lesion cellsen_US
dc.typeJournal article
dc.identifier.journalClinical & Experimental Metastasisen_US
dc.date.accepted2007-02-01
rioxxterms.funderUniversity of Wolverhamptonen_US
rioxxterms.identifier.projectUOWen_US
rioxxterms.versionAOen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2007-03-17en_US


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Archived with thanks to Clinical & Experimental Metastasis
Except where otherwise noted, this item's license is described as Archived with thanks to Clinical & Experimental Metastasis