Autocrine motility-stimulatory pathways of oral premalignant lesion cells
AuthorsYoung, M. Rita I.
Neville, Brad W.
Chi, Angela C.
Lathers, Deanne M. R.
Gillespie, M. Boyd
Day, Terry A.
MetadataShow full item record
AbstractPatients with premalignant oral lesions have varying levels of risk of developing oral squamous cell carcinoma (OSCC), whose aggressiveness requires increased motility. Not known is if and how premalignant oral lesion cells acquire the increased motility characteristic of OSCC. This was addressed by immunohistochemical analysis of banked premalignant lesion tissues and by functional analyses using cultures established from premalignant oral lesions and OSCC. These studies showed premalignant oral lesion cells and OSCC to be more motile than normal keratinocytes. Concomitantly, levels of ceramide were reduced. The activity of the protein phosphatase PP-2A, which restricts motility and which can be activated by ceramide, was also diminished. This was due to IL-10 released from premalignant lesion cells. Treatment with a membrane-permeable ceramide restored PP-2A activity and blocked migration. These studies show an autocrine motility-stimulatory pathway that is mediated in premalignant lesion cells by IL-10 through its reduction of ceramide levels and inhibition of PP-2A activity.
CitationAutocrine motility-stimulatory pathways of oral premalignant lesion cells 2007, 24 (2):131 Clinical & Experimental Metastasis
JournalClinical & Experimental Metastasis
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Archived with thanks to Clinical & Experimental Metastasis