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    Novel biomarkers in kidney disease: roles for cilia, Wnt signalling and ATMIN in polycystic kidney disease

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    Authors
    Goggolidou, P.
    Wilson, P.D.
    Issue Date
    2016-12-16
    
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    Abstract
    Biomarkers, the measurable indicators of biological conditions, are fast becoming a popular approach in providing information to track disease processes that could lead to novel therapeutic interventions for chronic conditions. Inherited, chronic kidney disease affects millions of people worldwide and although pharmacological treatments exist for some conditions, there are still patients whose only option is kidney dialysis and kidney transplantation. In the past 10 years, certain chronic kidney diseases have been reclassified as ciliopathies. Cilia in the kidney are antenna-like, sensory organelles that are required for signal transduction. One of the signalling pathways that requires the primary cilium in the kidney is Wnt signalling and it has three components such as canonical Wnt, non-canonical Wnt/planar cell olarity (PCP) and non-canonical Wnt/Ca2+ signalling. Identification of the novel role of ATM INteractor (ATMIN) as an effector molecule in the non-canonical Wnt/PCP pathway has intrigued us to investigate its potential role in chronic kidney disease. ATMIN could thus be an important biomarker in disease prognosis and treatment that might lighten the burden of chronic kidney disease and also affect on its progression.
    Citation
    Goggolidou, P., and Wilson, P.D. (2016) 'Novel biomarkers in kidney disease: roles for cilia, Wnt signalling and ATMIN in polycystic kidney disease', Biochemical Society Transactions, 44(6) pp. 1745-1751
    Publisher
    Portland Press Ltd
    Journal
    Biochemical Society Transactions
    URI
    http://hdl.handle.net/2436/621801
    DOI
    10.1042/BST20160124
    Additional Links
    https://www.ncbi.nlm.nih.gov/pubmed/27913685
    Type
    Journal article
    Language
    en
    ISSN
    1745-1751
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST20160124
    Scopus Count
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    Faculty of Science and Engineering

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