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dc.contributor.authorOfosu, Wendy Amy
dc.contributor.authorMohamed, Daahir
dc.contributor.authorCorcoran, Olivia
dc.contributor.authorOjo, Opeolu Oyejide
dc.date.accessioned2018-09-11T14:08:47Z
dc.date.available2018-09-11T14:08:47Z
dc.date.issued2018-01-19
dc.identifier.citationOfosu WA., Mohamed D., Corcoran O., Ojo, OO. 'The role of oestrogen receptor beta (ERβ) in the aetiology and treatment of type 2 diabetes mellitus', Current Diabetes Reviews, 15 (2) pp. 100-104. doi: 10.2174/1573399814666180119141836.
dc.identifier.issn1875-6417
dc.identifier.pmid29357808
dc.identifier.doi10.2174/1573399814666180119141836
dc.identifier.urihttp://hdl.handle.net/2436/621692
dc.description.abstractChallenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target. Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERβ show promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knock out mice indicate beneficial actions of selective agonists of ERβ receptor and underscore its therapeutic potential. Studies are needed to further elucidate the exact mechanism underlying the role of ERβ activation as a therapeutic approach in the management of type 2 diabetes.
dc.formatapplication/PDF
dc.language.isoen
dc.publisherBentham Science
dc.relation.urlhttp://www.eurekaselect.com/159214/article
dc.subjectERα
dc.subjectERβ
dc.subjectGLUT4
dc.subjectGPER
dc.subjectOestrogen receptor
dc.subjectinsulin resistance
dc.subjecttype 2 diabetes
dc.titleThe role of oestrogen receptor beta (ERβ) in the aetiology and treatment of type 2 diabetes mellitus
dc.typeJournal article
dc.identifier.journalCurrent Diabetes Reviews
dc.date.accepted2018-01-09
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUOW11092018OO2
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2019-01-19
dc.source.journaltitleCurrent diabetes reviews
dc.source.volume15
dc.source.issue2
dc.source.beginpage100
dc.source.endpage104
refterms.dateFCD2018-09-11T14:08:47Z
refterms.versionFCDAM


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