The role of oestrogen receptor beta (ERβ) in the aetiology and treatment of type 2 diabetes mellitus
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractChallenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target. Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERβ show promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knock out mice indicate beneficial actions of selective agonists of ERβ receptor and underscore its therapeutic potential. Studies are needed to further elucidate the exact mechanism underlying the role of ERβ activation as a therapeutic approach in the management of type 2 diabetes.
CitationOfosu WA., Mohamed D., Corcoran O., Ojo, OO. 'The role of oestrogen receptor beta (ERβ) in the aetiology and treatment of type 2 diabetes mellitus', Current Diabetes Reviews, 15 (2) pp. 100-104. doi: 10.2174/1573399814666180119141836.
JournalCurrent Diabetes Reviews
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
- Estrogen receptors: new players in diabetes mellitus.
- Authors: Barros RP, Machado UF, Gustafsson JA
- Issue date: 2006 Sep
- Participation of ERalpha and ERbeta in glucose homeostasis in skeletal muscle and white adipose tissue.
- Authors: Barros RP, Gabbi C, Morani A, Warner M, Gustafsson JA
- Issue date: 2009 Jul
- Oestrogen receptors pathways to oestrogen responsive elements: the transactivation function-1 acts as the keystone of oestrogen receptor (ER)beta-mediated transcriptional repression of ERalpha.
- Authors: Gougelet A, Mueller SO, Korach KS, Renoir JM
- Issue date: 2007 May
- Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha.
- Authors: Barros RP, Machado UF, Warner M, Gustafsson JA
- Issue date: 2006 Jan 31
- Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice.
- Authors: Mueller SO, Katzenellenbogen JA, Korach KS
- Issue date: 2004 Sep