Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsEngwa, Godwill Azeh
Nwalo, Friday Nweke
Chikezie, Claribel Chidimma
Onyia, Christie Oby
Ojo, Opeolu Oyejide
Mbacham, Wilfred Fon
Ubi, Benjamin Ewa
MetadataShow full item record
AbstractThe association between ABCC8 gene C49620T polymorphism and type 2 diabetes (T2D) in populations of diverse ethnic backgrounds has been reported. However, such occurrence in an African population is yet to be established. This case-control study involving 73 T2D and 75 non-diabetic (ND) patients investigated the occurrence of this polymorphism among T2D patients in Nigeria and assessed its relationship with body lipids of patients. Demographic and clinical characteristics of patients were collected and lipid profile indices including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were assayed. Restriction fragment length polymorphism-PCR (RFLP-PCR) was employed to genotype the ABCC8-C49620T polymorphism using PstI restriction enzyme. This study revealed significantly (p < 0.05) higher prevalence of the T allele of the ABCC8 gene in T2D patients (33.1%) compared to ND patients (28.0%). The mutant TT genotype was also higher than the CC and CT genotypes in T2D patients compared to ND patients but did not show any significant risk (p>0.05) of T2D for the unadjusted codominant, dominant and recessive models. Following age adjustment, the mutant genotypes (CT and TT) showed significant (p<0.05) risk of T2D for all the models with the recessive model presenting the greatest risk of T2D (OR: 2.39, 95% CI: 1.16-4.91, p<0.018). The TT genotype significantly (p<0.05) associated with high level of HDL and reduced levels of TC, TG and LDL in non-diabetic patients but was not associated with any of the demographic and clinical characteristics among T2D patients. ABCC8 C49620T polymorphism showed possible association with T2D marked by predominance of the mutant TT genotype in T2D patients. However, the relationship between TT genotype and lipid abnormalities for possible beneficial effect on people suffering from T2D is unclear.
CitationEngwa GA., Nwalo FN., Chikezie CC., Onyia CO., Ojo., OO, Mbacham WF., Ubi BE. (2018) 'Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population, BMC Medical Genetics, 19 (78)
JournalBMC Medical Genetics
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
- Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab.
- Authors: Matharoo K, Arora P, Bhanwer AJ
- Issue date: 2013 Sep 15
- The common C49620T polymorphism in the sulfonylurea receptor gene (ABCC8), pancreatic beta cell function and long-term diabetic complications in obese patients with long-lasting type 2 diabetes mellitus.
- Authors: Stefanski A, Majkowska L, Ciechanowicz A, Frankow M, Safranow K, Parczewski M, Pilarska K
- Issue date: 2007 May
- Association of C49620T ABCC8 polymorphism with anthropometric and metabolic parameters in patients with autosomal dominant polycystic kidney disease: a preliminary study.
- Authors: Pietrzak-Nowacka M, Safranow K, Bińczak-Kuleta A, Rózański J, Ciechanowski K, Ciechanowicz A
- Issue date: 2012
- A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients.
- Authors: Zhou X, Chen C, Yin D, Zhao F, Bao Z, Zhao Y, Wang X, Li W, Wang T, Jin Y, Lv D, Lu Q, Yin X
- Issue date: 2019 Aug 15
- Association of SERPINE1 rs6092 with type 2 diabetes and related metabolic traits in a Chinese population.
- Authors: Fan Q, Li H, Qin Y, Li L, Chen L, Zhang L, Lv Y, Liang D, Liang Y, Long T, Xie L, Yang H, Dong C, Zhang H
- Issue date: 2018 Jun 30