Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population
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Authors
Engwa, Godwill AzehNwalo, Friday Nweke
Chikezie, Claribel Chidimma
Onyia, Christie Oby
Ojo, Opeolu Oyejide
Mbacham, Wilfred Fon
Ubi, Benjamin Ewa
Issue Date
2018-05-12
Metadata
Show full item recordAbstract
The association between ABCC8 gene C49620T polymorphism and type 2 diabetes (T2D) in populations of diverse ethnic backgrounds has been reported. However, such occurrence in an African population is yet to be established. This case-control study involving 73 T2D and 75 non-diabetic (ND) patients investigated the occurrence of this polymorphism among T2D patients in Nigeria and assessed its relationship with body lipids of patients. Demographic and clinical characteristics of patients were collected and lipid profile indices including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were assayed. Restriction fragment length polymorphism-PCR (RFLP-PCR) was employed to genotype the ABCC8-C49620T polymorphism using PstI restriction enzyme. This study revealed significantly (p < 0.05) higher prevalence of the T allele of the ABCC8 gene in T2D patients (33.1%) compared to ND patients (28.0%). The mutant TT genotype was also higher than the CC and CT genotypes in T2D patients compared to ND patients but did not show any significant risk (p>0.05) of T2D for the unadjusted codominant, dominant and recessive models. Following age adjustment, the mutant genotypes (CT and TT) showed significant (p<0.05) risk of T2D for all the models with the recessive model presenting the greatest risk of T2D (OR: 2.39, 95% CI: 1.16-4.91, p<0.018). The TT genotype significantly (p<0.05) associated with high level of HDL and reduced levels of TC, TG and LDL in non-diabetic patients but was not associated with any of the demographic and clinical characteristics among T2D patients. ABCC8 C49620T polymorphism showed possible association with T2D marked by predominance of the mutant TT genotype in T2D patients. However, the relationship between TT genotype and lipid abnormalities for possible beneficial effect on people suffering from T2D is unclear.Citation
Engwa GA., Nwalo FN., Chikezie CC., Onyia CO., Ojo., OO, Mbacham WF., Ubi BE. (2018) 'Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population, BMC Medical Genetics, 19 (78)Publisher
Springer NatureJournal
BMC Medical GeneticsPubMed ID
29751826Type
Journal articleLanguage
enISSN
1471-2350ae974a485f413a2113503eed53cd6c53
10.1186/s12881-018-0601-1
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- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
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