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dc.contributor.authorChen, Ruoling
dc.contributor.authorHu, Zhi
dc.contributor.authorWei, Li
dc.contributor.authorMa, Ying
dc.contributor.authorLiu, Zhuming
dc.contributor.authorCopeland, John R
dc.date.accessioned2018-08-30T09:09:56Z
dc.date.available2018-08-30T09:09:56Z
dc.date.issued2011-09-23
dc.identifier.issn1932-6203
dc.identifier.pmid21966372
dc.identifier.doi10.1371/journal.pone.0024817
dc.identifier.urihttp://hdl.handle.net/2436/621653
dc.description.abstractCurrent knowledge about incident dementia is mainly derived from studies undertaken in the West, showing that dementia is related to older age, low socio-economic status, lack of social network, depression and cardiovascular disease risk factors. We know little about incidence and predictors of dementia in China, where the prevalence is increasing and the patterns of risk factors are different. Using a standard interview method, we examined 1526 non-demented people aged ≥65 years who had at least minimal educational level in China in a 7.5-year follow up. Incident dementia was diagnosed by GMS-AGECAT algorithms and psychiatrists. Age-standardised incidence of dementia was 14.7 per 1000 person-years (95%CI 11.3-18.2 per 1000 person-years). The increased risk was significantly associated with age, female gender (adjusted odds ratio 2.48, 95%CI 1.20-5.13), low educational levels, smoking, angina (2.58, 1.01-6.59) and living with fewer family members. Among participants with low educational level, the increased risk was associated with higher income, and with the highest and lowest occupational classes; adjusted odds ratio 2.74 (95%CI 1.12-6.70) for officers/teachers, 3.11 (1.61-6.01) for manual labourers/peasants. Our findings of high incidence of dementia and increased risk among people having low education levels but high income suggest a more potential epidemic and burden of dementia populations in China. Maintaining social network and activities and reducing cardiovascular factors in late life could be integrated into current multi-faceted preventive strategies for curbing the epidemic of dementia.
dc.formatapplication/PDF
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024817
dc.titleIncident dementia in a defined older Chinese population.
dc.typeJournal article
dc.identifier.journalPLoS One
dc.date.accepted2011-08-18
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUOW300818RC
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2011-09-23
dc.source.journaltitlePloS one
refterms.dateFCD2018-08-30T09:09:56Z
refterms.versionFCDAM
refterms.dateFOA2018-08-30T09:09:56Z


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