Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Machado, J C
Metsios, George S.
Flouris, A D
MetadataShow full item record
AbstractThe association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways. Some athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/β-catenin signalling pathways with low BMD in elite and pre-elite dancers (impact sport athletes). The study included three phases: (1) 151 elite and pre-elite dancers were screened for the presence of low BMD and traditional osteoporosis risk factors (low body weight, menstrual disturbances, low energy availability); (2) a genetic association study was conducted in 151 elite and pre-elite dancers and age- and sex- controls; (3) serum sclerostin was measured in 101 pre-elite dancers and age- and sex-matched controls within a 3-year period. Eighty dancers revealed low BMD: 56.3% had at least one traditional osteoporosis risk factor, whereas 28.6% did not display any risk factor (37.2% revealed traditional osteoporosis risk factors, but had normal BMD). Body weight, menstrual disturbances and energy availability did not fully predict bone mass acquisition. Instead, genetic polymorphisms in the ER and Wnt/β-catenin pathways were found to be risk factors for low BMD in elite dancers. Sclerostin was significantly increased in dancers compared to controls during the 3-year follow-up (p < 0.05).
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
- Bone Mineral Density in Elite DanceSport Athletes.
- Authors: Kruusamäe H, Maasalu K, Jürimäe J
- Issue date: 2016 Mar
- Bone mineral density in vocational and professional ballet dancers.
- Authors: Amorim T, Koutedakis Y, Nevill A, Wyon M, Maia J, Machado JC, Marques F, Metsios GS, Flouris AD, Adubeiro N, Nogueira L, Dimitriou L
- Issue date: 2017 Oct
- Retired elite female ballet dancers and nonathletic controls have similar bone mineral density at weightbearing sites.
- Authors: Khan KM, Green RM, Saul A, Bennell KL, Crichton KJ, Hopper JL, Wark JD
- Issue date: 1996 Oct
- Energetic efficiency, menstrual irregularity, and bone mineral density in elite professional female ballet dancers.
- Authors: Doyle-Lucas AF, Akers JD, Davy BM
- Issue date: 2010
- Bone mineral density in adolescent elite ballet dancers.
- Authors: Wielandt T, van den Wyngaert T, Uijttewaal JR, Huyghe I, Maes M, Stassijns G
- Issue date: 2019 Sep