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    Separation and purification of alkaloids from Sophora flavescens Ait. by focused microwave-assisted aqueous two-phase extraction coupled with reversed micellar extraction

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    Authors
    Zhang, Wei
    Liu, Xiaoqin
    Fan, Huajun
    Zhu, Dan
    Wu, Xuehao
    Huang, Xiaowen
    Tang, James
    Issue Date
    2016-04-06
    
    Metadata
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    Abstract
    Based on advantages of microwave-assisted extraction (MAE), aqueous two-phase extraction (ATPE)and reversed micellar extraction (RME), a novel method of extraction and purification of alkaloids fromSophora flavescens Ait. was put forward by using focused microwave-assisted aqueous two-phase extrac-tion (FMAATPE) coupled with the reversed micellar extraction (RME). The aqueous two-phase system(ATPS) consisted of ethanol and ammonia sulfate was used as extracting solvent, FMAATPE conditionssuch as the compositions of ATPS, and the extraction temperature, extraction time and solvent-to-materials ratio were optimized by orthogonal test through HPLC analysis. Then alkaloids extracted byFMAATPE were further purified with reverse micelles of sodium dodecyl benzene sulfonate/isooctane/n-octanol. The relative purity of total alkaloids in the product was improved greatly by RME from 58.30% to88.75% (w/w), and purification recovery was higher than that of solvent extraction, ion exchange resinand macroporous adsorption resin. Moreover, the reverse micelles used could be readily recycled byadding salt and water, keeping better extraction performance with about 80% (w/w) of recovery. Thus,the proposed method is easy to adjust, operate and enlarge for better application prospect; the purity ofalkaloids obtained meets the requirements of the compound drug preparation.
    Publisher
    Elsevier B.V.
    Journal
    Industrial Crops and Products
    URI
    http://hdl.handle.net/2436/621533
    DOI
    10.1016/j.indcrop.2016.03.052
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0926669016302126
    Type
    Journal article
    Language
    en
    ISSN
    09266690
    Sponsors
    The Science and Technology Project of Guangzhou (No. 2008Z1-E301) and Faculty Development fund Project of Guangdong Pharmaceutical University (No. 52104109)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.indcrop.2016.03.052
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    Faculty of Science and Engineering

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