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dc.contributor.authorMa, Shengnan
dc.contributor.authorZhou, Jie
dc.contributor.authorWali, Aisha Roshan Mohamed
dc.contributor.authorHe, Yiyan
dc.contributor.authorXu, Xianghui
dc.contributor.authorTang, James Zhenggui
dc.contributor.authorGu, Zhongwei
dc.date.accessioned2018-07-12T13:38:56Z
dc.date.available2018-07-12T13:38:56Z
dc.date.issued2015-08
dc.identifier.citationSelf-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery. 2015, 26 (8):219 J Mater Sci Mater Med
dc.identifier.issn1573-4838
dc.identifier.pmid26238777
dc.identifier.doi10.1007/s10856-015-5550-z
dc.identifier.urihttp://hdl.handle.net/2436/621492
dc.description.abstractIn this study, the amphiphilic fluorinated peptide dendrons functionalized dextran (FPD-HZN-Dex) via an acid-sensitive hydrazone linkage was successfully designed and prepared for the first time. We demonstrated a spontaneous self-assembly of amphiphilic FPD-HZN-Dex into the well-defined nanoparticles with the core-shell architecture in aqueous media, which is attributed to the efficient amphiphilic functionalization of dextran by the hydrophobic fluorinated peptide dendrons. The spherical morphology, uniform particle size and good storage stability of the prepared FPD-HZN-Dex nanoparticles were characterized by dynamic light scattering and transmission electron microscopy, respectively. In vitro drug release studies showed a controlled and pH dependent hydrophobic drug release profile. The cell viability assays show excellent biocompatibility of the FPD-HZN-Dex nanoparticles for both normal cells and tumor cells. Moreover, the FPD-HZN-Dex self-assembled systems based on pH-sensitive hydrazone linkage also can serve as stimulus bioresponsive carriers for on-demand intracellular drug delivery. These self-assembled nanoparticles exhibit a stimulus-induced response to endo/lysosome pH (pH 5.0) that causes their disassembly over time, enabling controlled release of encapsulated DOX. This work has unveiled a unique non-covalent interaction useful for engineering amphiphilic dendrons or dendrimers self-assembled systems.
dc.description.sponsorshipThe European Commission Research and Innovation (PIRSES-GA-2011-295218)
dc.language.isoen
dc.subjectPeptide Dendron
dc.subjectfluorinated
dc.subjectpH sensitive
dc.subjectfunctionalised dextran nanoparticles
dc.subjectDOX intracellular drug delivery
dc.subject.meshAntineoplastic Agents
dc.subject.meshBiocompatible Materials
dc.subject.meshCell Survival
dc.subject.meshDendrimers
dc.subject.meshDextrans
dc.subject.meshDoxorubicin
dc.subject.meshDrug Carriers
dc.subject.meshDrug Delivery Systems
dc.subject.meshDrug Stability
dc.subject.meshHEK293 Cells
dc.subject.meshHep G2 Cells
dc.subject.meshHumans
dc.subject.meshHydrogen-Ion Concentration
dc.subject.meshMass Spectrometry
dc.subject.meshMaterials Testing
dc.subject.meshNanoparticles
dc.subject.meshParticle Size
dc.subject.meshPeptides
dc.subject.meshPolylysine
dc.subject.meshSpectroscopy, Fourier Transform Infrared
dc.titleSelf-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery.
dc.typeJournal article
dc.identifier.journalJournal of materials science. Materials in medicine
html.description.abstractIn this study, the amphiphilic fluorinated peptide dendrons functionalized dextran (FPD-HZN-Dex) via an acid-sensitive hydrazone linkage was successfully designed and prepared for the first time. We demonstrated a spontaneous self-assembly of amphiphilic FPD-HZN-Dex into the well-defined nanoparticles with the core-shell architecture in aqueous media, which is attributed to the efficient amphiphilic functionalization of dextran by the hydrophobic fluorinated peptide dendrons. The spherical morphology, uniform particle size and good storage stability of the prepared FPD-HZN-Dex nanoparticles were characterized by dynamic light scattering and transmission electron microscopy, respectively. In vitro drug release studies showed a controlled and pH dependent hydrophobic drug release profile. The cell viability assays show excellent biocompatibility of the FPD-HZN-Dex nanoparticles for both normal cells and tumor cells. Moreover, the FPD-HZN-Dex self-assembled systems based on pH-sensitive hydrazone linkage also can serve as stimulus bioresponsive carriers for on-demand intracellular drug delivery. These self-assembled nanoparticles exhibit a stimulus-induced response to endo/lysosome pH (pH 5.0) that causes their disassembly over time, enabling controlled release of encapsulated DOX. This work has unveiled a unique non-covalent interaction useful for engineering amphiphilic dendrons or dendrimers self-assembled systems.


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