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    Self-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery.

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    Authors
    Ma, Shengnan
    Zhou, Jie
    Wali, Aisha Roshan Mohamed
    He, Yiyan
    Xu, Xianghui
    Tang, James Zhenggui
    Gu, Zhongwei
    Issue Date
    2015-08
    
    Metadata
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    Abstract
    In this study, the amphiphilic fluorinated peptide dendrons functionalized dextran (FPD-HZN-Dex) via an acid-sensitive hydrazone linkage was successfully designed and prepared for the first time. We demonstrated a spontaneous self-assembly of amphiphilic FPD-HZN-Dex into the well-defined nanoparticles with the core-shell architecture in aqueous media, which is attributed to the efficient amphiphilic functionalization of dextran by the hydrophobic fluorinated peptide dendrons. The spherical morphology, uniform particle size and good storage stability of the prepared FPD-HZN-Dex nanoparticles were characterized by dynamic light scattering and transmission electron microscopy, respectively. In vitro drug release studies showed a controlled and pH dependent hydrophobic drug release profile. The cell viability assays show excellent biocompatibility of the FPD-HZN-Dex nanoparticles for both normal cells and tumor cells. Moreover, the FPD-HZN-Dex self-assembled systems based on pH-sensitive hydrazone linkage also can serve as stimulus bioresponsive carriers for on-demand intracellular drug delivery. These self-assembled nanoparticles exhibit a stimulus-induced response to endo/lysosome pH (pH 5.0) that causes their disassembly over time, enabling controlled release of encapsulated DOX. This work has unveiled a unique non-covalent interaction useful for engineering amphiphilic dendrons or dendrimers self-assembled systems.
    Citation
    Self-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery. 2015, 26 (8):219 J Mater Sci Mater Med
    Journal
    Journal of materials science. Materials in medicine
    URI
    http://hdl.handle.net/2436/621492
    DOI
    10.1007/s10856-015-5550-z
    PubMed ID
    26238777
    Type
    Journal article
    Language
    en
    ISSN
    1573-4838
    Sponsors
    The European Commission Research and Innovation (PIRSES-GA-2011-295218)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10856-015-5550-z
    Scopus Count
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    Faculty of Science and Engineering

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