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dc.contributor.authorHenderson, Scott H.
dc.contributor.authorWest, Ryan A.
dc.contributor.authorWard, Simon E.
dc.contributor.authorHoney, Mark A.
dc.date.accessioned2018-07-03T08:41:32Z
dc.date.available2018-07-03T08:41:32Z
dc.date.issued2018-06-20
dc.identifier.citationHenderson, SH., West, RA., Ward, RA., and Honey, MA. 'Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions', Royal Society Open Science, 5 (6)
dc.identifier.issn2054-5703
dc.identifier.doi10.1098/rsos.180333
dc.identifier.urihttp://hdl.handle.net/2436/621407
dc.description.abstractThe halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.
dc.formatapplication/PDF
dc.language.isoen
dc.publisherThe Royal Society Publishing
dc.relation.urlhttp://rsos.royalsocietypublishing.org/lookup/doi/10.1098/rsos.180333
dc.subjectHalodecarboxylation
dc.subjectSelective Halogenation
dc.subjectMild Conditions
dc.titleMetal-free selective mono-halodecarboxylation of heteroarenes under mild conditions
dc.typeJournal article
dc.identifier.journalRoyal Society Open Science
dc.date.accepted2018-04-10
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUOW03072018MH
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-06-20
dc.source.volume5
dc.source.issue6
refterms.dateFCD2018-10-19T09:24:44Z
refterms.versionFCDAM
refterms.dateFOA2018-10-18T09:24:43Z
html.description.abstractThe halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.


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