Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions
Abstract
The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.Citation
Henderson, SH., West, RA., Ward, RA., and Honey, MA. 'Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions', Royal Society Open Science, 5 (6)Publisher
The Royal Society PublishingJournal
Royal Society Open ScienceType
Journal articleLanguage
enISSN
2054-5703ae974a485f413a2113503eed53cd6c53
10.1098/rsos.180333
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