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dc.contributor.authorSolanki, Viraj
dc.contributor.authorBall, Patrick
dc.contributor.authorMorrissey, Hana
dc.date.accessioned2018-06-05T11:59:45Z
dc.date.available2018-06-05T11:59:45Z
dc.date.issued2018-04-28
dc.identifier.citationVolume 4; Issue 4 (A) April 2018; Page No. 3253-3261
dc.identifier.issn2395-6429
dc.identifier.doi10.24327/23956429.ijcmpr20180436
dc.identifier.urihttp://hdl.handle.net/2436/621326
dc.description.abstractAim: The aim of this review was to better understand the risks and care issues associated with poorly managed type 2 diabetes mellitus, in relation to poor prognosis of bipolar disorder. Methods: A systematic review of the literature was conducted using combined terms “Type 2 diabetes” OR “Insulin Resistance” AND “Bipolar Disorder” AND “Outcome” AND “Course of illness” in a variety of databases. The publications were all filtered following pre-defined criteria. Results: Nine primary articles were selected. The analysis showed that in patients diagnosed with type 2 diabetes, there was association of higher uncontrolled bipolar symptoms period corresponding with the severity of the bipolar disorder. Individuals with bipolar disorder and diabetes mellitus experienced neurodegenerative disorders with more depressive symptoms. Additionally, higher rate of non-compliance was identified with the use of bipolar disorder medications. Conclusions: Overall results indicated an overlapping clinical pathophysiology relationship between both diabetes mellitus and neuropsychiatric disorders. There is a need for collaborative care among psychiatric and general medical providers.
dc.formatapplication/PDF
dc.language.isoen
dc.publisherInternational Journal of Current Medical and Pharmaceutical Research
dc.relation.urlhttp://journalcmpr.com/issues/disease-modifying-effects-type-2-diabetes-mellitus-and-bipolar-disorder-comorbidity
dc.subjectbipolar disorder
dc.subjectType 2 diabetes
dc.subjectInsulin Resistance
dc.subjectMetabolic Syndrome
dc.subjectTreatment Response
dc.titleDisease-modifying effects of type 2 diabetes mellitus and bipolar disorder comorbidity
dc.typeJournal article
dc.identifier.journalInternational Journal of Current Medical and Pharmaceutical Research
dc.date.accepted2018-03-24
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUOW05062018HM1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-06-05
dc.source.volume4
dc.source.issue4
dc.source.beginpage3253
dc.source.endpage3261
refterms.dateFCD2018-10-19T09:23:24Z
refterms.versionFCDVoR
refterms.dateFOA2018-06-05T00:00:00Z
html.description.abstractAim: The aim of this review was to better understand the risks and care issues associated with poorly managed type 2 diabetes mellitus, in relation to poor prognosis of bipolar disorder. Methods: A systematic review of the literature was conducted using combined terms “Type 2 diabetes” OR “Insulin Resistance” AND “Bipolar Disorder” AND “Outcome” AND “Course of illness” in a variety of databases. The publications were all filtered following pre-defined criteria. Results: Nine primary articles were selected. The analysis showed that in patients diagnosed with type 2 diabetes, there was association of higher uncontrolled bipolar symptoms period corresponding with the severity of the bipolar disorder. Individuals with bipolar disorder and diabetes mellitus experienced neurodegenerative disorders with more depressive symptoms. Additionally, higher rate of non-compliance was identified with the use of bipolar disorder medications. Conclusions: Overall results indicated an overlapping clinical pathophysiology relationship between both diabetes mellitus and neuropsychiatric disorders. There is a need for collaborative care among psychiatric and general medical providers.


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