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dc.contributor.authorHeendeniya, Saumya
dc.contributor.authorRatnasooriya, W D
dc.contributor.authorPathirana, R N
dc.date.accessioned2018-02-15T10:24:20Z
dc.date.available2018-02-15T10:24:20Z
dc.date.issued2018-01-01
dc.identifier.citationHeendeniya, S., Ratnasooriya, WD., Pathirana, RN., 'In vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatum', Journal of Pharmacognosy and Phytochemistry, 7 (1) pp. 1759-1763
dc.identifier.issn2278-4136
dc.identifier.urihttp://hdl.handle.net/2436/621105
dc.description.abstractThis study examined the anti-inflammatory potential of an aquous root extract of Syzygium caryophyllatum (Family: Myrtaceae) and reference drug Declofenac sodium, invitro using heat induced egg albumin denaturation bio assay technique. The concentrations of the root extract used were 781.25, 1562.5, 3125, 6250 and 12500 μg/mL. While diclofenac sodum were 78.12, 156.25, 312.5, 625, 1250 and 2500 μg/mL. Both the extract (r2 = 0.97; P<0.05) and Diclofenac sodium (r2 = 0.87; P<0.05) displayed marked and concentration dependent inhibition of heat-induced protein denaturation with IC50 value of 6.229 *103 μ g/ml and ~1.704*108 μg/mL respectively. Phytochemical analysis of the extract revealed the presence of the flavanoids, phenols, tanins, alkaloids, saponins and amino acids. It is concluded that the aquous root extract of Sri Lankan grown Syzygium caryophyllatum possess marked in vitro antiinflammatory activity which is mediated possibly by flavanoids, tanins and alkaloids. This is a novel finding. Further the results scientifically justify the use of roots of Syzygium caryophyllatum in Sri Lankan traditional medicine to treat inflammation.
dc.language.isoen
dc.publisherSociety of Pharmacognosy and Phytochemistry
dc.relation.urlhttp://www.phytojournal.com/archives/?year=2018&vol=7&issue=1&ArticleId=2780&si=false
dc.subjectSyzygium caryophyllatum
dc.subjectanti-inflammation
dc.subjectinflammation
dc.subjectegg albumin denaturation assay
dc.subjectSri Lankan traditional medicine
dc.titleIn vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatum
dc.typeJournal article
dc.identifier.journalJournal of Pharmacognosy and Phytochemistry
dc.date.accepted2017-12-31
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUoW150218SNH
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2018-02-15
dc.source.volume7
dc.source.issue1
dc.source.beginpage1759
dc.source.endpage1763
refterms.dateFCD2018-10-19T09:28:38Z
refterms.versionFCDVoR
refterms.dateFOA2018-02-15T00:00:00Z
html.description.abstractThis study examined the anti-inflammatory potential of an aquous root extract of Syzygium caryophyllatum (Family: Myrtaceae) and reference drug Declofenac sodium, invitro using heat induced egg albumin denaturation bio assay technique. The concentrations of the root extract used were 781.25, 1562.5, 3125, 6250 and 12500 μg/mL. While diclofenac sodum were 78.12, 156.25, 312.5, 625, 1250 and 2500 μg/mL. Both the extract (r2 = 0.97; P<0.05) and Diclofenac sodium (r2 = 0.87; P<0.05) displayed marked and concentration dependent inhibition of heat-induced protein denaturation with IC50 value of 6.229 *103 μ g/ml and ~1.704*108 μg/mL respectively. Phytochemical analysis of the extract revealed the presence of the flavanoids, phenols, tanins, alkaloids, saponins and amino acids. It is concluded that the aquous root extract of Sri Lankan grown Syzygium caryophyllatum possess marked in vitro antiinflammatory activity which is mediated possibly by flavanoids, tanins and alkaloids. This is a novel finding. Further the results scientifically justify the use of roots of Syzygium caryophyllatum in Sri Lankan traditional medicine to treat inflammation.


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