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dc.contributor.authorFenton, Sally A. M.
dc.contributor.authorSandoo, Aamer
dc.contributor.authorMetsios, George S.
dc.contributor.authorDuda, Joan L.
dc.contributor.authorKitas, George D.
dc.contributor.authorVeldhuijzen van Zanten, Jet J.C.S.
dc.date.accessioned2018-02-12T12:38:24Z
dc.date.available2018-02-12T12:38:24Z
dc.date.issued2018-02-21
dc.identifier.citationFenton, S.A., Sandoo, A., Metsios, G.S., Duda, J.L., Kitas, G.D., & Zanten, J.J. (2018). Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis. Microvascular research, 117 (may 2018), pp 57-60.
dc.identifier.issn0026-2862
dc.identifier.doi10.1016/j.mvr.2018.01.005
dc.identifier.urihttp://hdl.handle.net/2436/621099
dc.description.abstractBackground: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.
dc.formatapplication/pdf
dc.language.isoen
dc.publisherElsevier
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S002628621730242X
dc.subjectCardiovascular disease
dc.subjectEndothelial function
dc.subjectRheumatoid arthritis
dc.subjectSedentary behaviour
dc.subjectUltrasonography
dc.titleSitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis
dc.typeJournal article
dc.identifier.journalMicrovascular Research
dc.date.accepted2018-01-14
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.project120218GSM
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2019-02-21
dc.source.volume117
dc.source.issueMay 2018
dc.source.beginpage57
dc.source.endpage60
refterms.dateFCD2018-10-19T09:12:35Z
refterms.versionFCDAM
refterms.dateFOA2019-05-01T00:00:00Z
html.description.abstractBackground: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. Objectives: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. Methods: Sixty-eight RA patients (Mage = 55±12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). Results: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = − 3.25, p = .02, 95% CI [– 6.07, – .42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). Conclusion: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.


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