Combination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process
Abstract
Density-dependent Drucker-Prager Cap (DPC) model is widely used for assessing the compaction behaviour of powders due to its capability of capturing the various phenomena associated with the powder compaction process such as work hardening, nonlinear densification, and frictional and compressible behaviour of the powder. This paper presents a full description of the Drucker-Prager Cap model for the compaction behaviour of microcrystalline cellulose (MCC) Avicel PH101 pharmaceutical powder. The experimental calibration process of Drucker-Prager Cap is detailed and all model parameters are calculated as a function of powder relative density. Also, the calibrated parameters are implemented in finite element code to perform a numerical simulation of a typical pharmaceutical tablet. The results showed that the finite element model (FEM) was able to accurately predict the compaction behaviour of the microcrystalline cellulose powder. Furthermore, the finite element predictions of stress and density distributions of the powders during the compaction were used to analyse the failure mechanisms associated with tableting.Citation
Baroutaji, A., Lenihan, S., Bryan, K. (2017) 'Combination of finite element method and Drucker-Prager Cap material model for simulation of pharmaceutical tableting process', Materialwissenschaft und Werkstofftechnik, 48 (11), pp. 1133-1145.Publisher
WileyJournal
Materialwissenschaft und WerkstofftechnikAdditional Links
http://doi.wiley.com/10.1002/mawe.201700048Type
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by Wiley in Materialwissenschaft und Werkstofftechnik on 05/12/2017, available online: https://doi.org/10.1002/mawe.201700048 The accepted version of the publication may differ from the final published version.ISSN
1521-4052ae974a485f413a2113503eed53cd6c53
10.1002/mawe.201700048
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