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dc.contributor.authorMolina, Carlos
dc.contributor.authorKaialy, Waseem
dc.contributor.authorChen, Qiao
dc.contributor.authorCommandeur, Daniel
dc.contributor.authorNokhodchi, Ali
dc.date.accessioned2018-01-09T09:25:56Z
dc.date.available2018-01-09T09:25:56Z
dc.date.issued2017-12-19
dc.identifier.citationMolina C., Kaialy W., Chen Q., Commandeur D., Nokhodchi A. (2017) 'Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations', Drug Delivery and Translational Research, 8 (6) pp. 1769-1780. doi: 10.1007/s13346-017-0462-8
dc.identifier.issn2190-393X
dc.identifier.doi10.1007/s13346-017-0462-8
dc.identifier.urihttp://hdl.handle.net/2436/621029
dc.description.abstractSpray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactoseleucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfate’s aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, α- lactose, and β-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 μm) suitable as a carrier in DPI formulations.
dc.language.isoen
dc.publisherSpringer
dc.relation.urlhttp://link.springer.com/10.1007/s13346-017-0462-8
dc.subjectDry powder inhaler
dc.subjectSpray-drying
dc.subjectAgglomeration
dc.subjectSalbutamol sulfate
dc.subjectLeucine
dc.titleAgglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations
dc.typeJournal article
dc.identifier.journalDrug Delivery and Translational Research
dc.date.accepted2017-12
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.project090118WK
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2018-12-18
dc.source.volume8
dc.source.issue6
dc.source.beginpage1769
dc.source.endpage1780
refterms.dateFCD2018-10-19T09:26:31Z
refterms.versionFCDVoR
html.description.abstractSpray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactoseleucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfate’s aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, α- lactose, and β-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 μm) suitable as a carrier in DPI formulations.


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