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dc.contributor.authorKrucińska, Izabella
dc.contributor.authorŻywicka, Bogusława
dc.contributor.authorKomisarczyk, Agnieszka
dc.contributor.authorSzymonowicz, Maria
dc.contributor.authorKowalska, Stanisława
dc.contributor.authorZaczyńska, Ewa
dc.contributor.authorStruszczyk, Marcin
dc.contributor.authorCzarny, Anna
dc.contributor.authorJadczyk, Piotr
dc.contributor.authorUmińska-Wasiluk, Barbara
dc.contributor.authorRybak, Zbigniew
dc.contributor.authorKowalczuk, Marek
dc.date.accessioned2018-01-08T09:53:30Z
dc.date.available2018-01-08T09:53:30Z
dc.date.issued2017-11-29
dc.identifier.citationKrucińska I., Żywicka B., Komisarczyk A., Szymonowicz M., Kowalska S., Zaczyńska E., Struszczyk M., Czarny A., Jadczyk P., Umińska-Wasiluk B., Rybak Z., Kowalczuk M. (2017) 'Biological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity' Molecules 22 (12) 2092 doi: 10.3390/molecules22111852
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules22122092
dc.identifier.urihttp://hdl.handle.net/2436/621022
dc.description.abstractIn response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(L-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and L-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.
dc.language.isoen
dc.publisherMDPI
dc.relation.urlhttp://www.mdpi.com/1420-3049/22/12/2092
dc.subjectbiotoxicity
dc.subjectbiodegradation
dc.subjectcytotoxicity
dc.subjectgenotoxicity
dc.subjecthemocompatability
dc.subjectnonwoven fabrics
dc.subjectbone implant
dc.subjectpoly(L-lactide-co-glycolide)
dc.subjectsynthetic poly([R,S]-3-hydroxybutyrate)
dc.subjectencapsulated growth factor
dc.titleBiological properties of low-toxicity PLGA and PLGA/PHB fibrous nanocomposite implants for osseous tissue regeneration. Part I: evaluation of potential biotoxicity
dc.typeJournal article
dc.identifier.journalMolecules
dc.date.accepted2017-11-27
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectStructural Founds in the frame of “Biodegradable fibrous products” project (acronym BIOGRATEX) no. POIG01.03.01-00-07/08-09)
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2018-01-08
dc.source.volume22
dc.source.issue12
refterms.dateFCD2018-10-19T09:23:24Z
refterms.versionFCDVoR
refterms.dateFOA2018-01-08T00:00:00Z
html.description.abstractIn response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(L-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and L-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.


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