Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry.

Yates, Sally A; Dempster, Nicola M; Murphy, Mark F; Moore, Sharon A

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Authors

Yates, Sally A
Dempster, Nicola M
Murphy, Mark F
Moore, Sharon A

Issue Date

2017-05-16

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Abstract

The lipid peroxidation product malondialdehyde forms M1 dG adducts with guanine bases in genomic DNA. The analysis of these adducts is important as a biomarker of lipid peroxidation, oxidative stress and inflammation which may be linked to disease risk or exposure to a range of chemicals.

Citation

Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry. 2017, 31 (9):762-770 Rapid Commun. Mass Spectrom.

Publisher

Wiley

Journal

Rapid communications in mass spectrometry : RCM

URI

http://hdl.handle.net/2436/621014

DOI

10.1002/rcm.7843

PubMed ID

28231608

Type

Article

Language

Collections

Faculty of Science and Engineering

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