Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry

Yates, Sally A; Dempster, Nicola M; Murphy, Mark F; Moore, Sharon A

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Authors

Yates, Sally A
Dempster, Nicola M
Murphy, Mark F
Moore, Sharon A

Issue Date

2017-04-16

Metadata

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Abstract

The lipid peroxidation product malondialdehyde forms M1 dG adducts with guanine bases in genomic DNA. The analysis of these adducts is important as a biomarker of lipid peroxidation, oxidative stress and inflammation which may be linked to disease risk or exposure to a range of chemicals.

Citation

Yates, SA., Dempster, NM., Murphy, MF and Moore, SA. (2017) 'Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry'. Rapid Communications In Mass Spectrometry. 31 (9) pp. 762-770

Publisher

Wiley

Journal

Rapid Communications In Mass Spectrometry

URI

http://hdl.handle.net/2436/621014

DOI

10.1002/rcm.7843

PubMed ID

28231608

Type

Journal article

Language

Collections

Faculty of Science and Engineering

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Creative Commons

Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/