Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry

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Authors
Yates, Sally A
Dempster, Nicola M
Murphy, Mark F
Moore, Sharon A
Issue Date
2017-04-16

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Abstract
The lipid peroxidation product malondialdehyde forms M1 dG adducts with guanine bases in genomic DNA. The analysis of these adducts is important as a biomarker of lipid peroxidation, oxidative stress and inflammation which may be linked to disease risk or exposure to a range of chemicals.
Citation
Yates, SA., Dempster, NM., Murphy, MF and Moore, SA. (2017) 'Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography/tandem mass spectrometry'. Rapid Communications In Mass Spectrometry. 31 (9) pp. 762-770
Publisher
Wiley
Journal
Rapid Communications In Mass Spectrometry
URI
http://hdl.handle.net/2436/621014
DOI
10.1002/rcm.7843
PubMed ID
28231608
Type
Journal article
Language
en
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