Lithium overdose and delayed severe neurotoxicity – timing for renal replacement therapy and restarting of Lithium

de Cates, Angharad; Morlet, Julien; Antoun Reyad, Ayman; Tadros, George

dc.contributor.author	de Cates, Angharad
dc.contributor.author	Morlet, Julien
dc.contributor.author	Antoun Reyad, Ayman
dc.contributor.author	Tadros, George
dc.date.accessioned	2017-10-13T14:34:59Z
dc.date.available	2017-10-13T14:34:59Z
dc.date.issued	2017-10-25
dc.identifier.citation	de Cates AN., Morlet J., Antoun Reyad A., Tadros G. (2017) 'Lithium overdose and delayed severe neurotoxicity – timing for renal replacement therapy and restarting of Lithium', BMJ Case Reports,
dc.identifier.issn	1757-790X
dc.identifier.doi	10.1136/bcr-2017-222453
dc.identifier.uri	http://hdl.handle.net/2436/620769
dc.description.abstract	This is a case report of a gentleman in his sixties who presented to an English hospital following a significant Lithium overdose. He was monitored for 24 hours, and then renal replacement therapy was initiated after assessment by the renal team. As soon as the Lithium level returned to normal therapeutic levels (from 4.7mEq/L to 0.67mEq/L), Lithium was restarted by the medical team. At this point, the patient developed new slurred speech, and later catatonia. In this case report, we discuss the factors that could determine which patients are at risk of neurotoxicity following Lithium overdose, and the appropriate decision regarding when and how to consider initiation of renal replacement therapy and restarting of Lithium.
dc.language.iso	en
dc.publisher	BMJ Publishing Group Ltd
dc.relation.url	https://casereports.bmj.com/content/2017/bcr-2017-222453
dc.subject	Lithium
dc.subject	Neurotoxicity
dc.subject	Renal Replacement Therapy
dc.title	Lithium overdose and delayed severe neurotoxicity – timing for renal replacement therapy and restarting of Lithium
dc.type	Journal article
dc.identifier.journal	BMJ Case Reports
dc.date.accepted	2017-10-10
rioxxterms.funder	University of Wolverhampton
rioxxterms.identifier.project	UoW131017AAR
rioxxterms.version	AM
rioxxterms.licenseref.uri	https://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate	2018-03-01
refterms.dateFCD	2018-10-19T09:23:24Z
refterms.versionFCD	AM
refterms.dateFOA	2018-03-01T00:00:00Z
html.description.abstract	This is a case report of a gentleman in his sixties who presented to an English hospital following a significant Lithium overdose. He was monitored for 24 hours, and then renal replacement therapy was initiated after assessment by the renal team. As soon as the Lithium level returned to normal therapeutic levels (from 4.7mEq/L to 0.67mEq/L), Lithium was restarted by the medical team. At this point, the patient developed new slurred speech, and later catatonia. In this case report, we discuss the factors that could determine which patients are at risk of neurotoxicity following Lithium overdose, and the appropriate decision regarding when and how to consider initiation of renal replacement therapy and restarting of Lithium.