Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsDeli, Chariklia K
Fatouros, Ioannis G
Jamurtas, Athanasios Z
MetadataShow full item record
AbstractExercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.
CitationIron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children. 2017, 2017:4120421 Oxid Med Cell Longev
PublisherHindawi Publishing Corporation
JournalOxidative medicine and cellular longevity
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Archived with thanks to Oxidative medicine and cellular longevity
- Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise.
- Authors: Michailidis Y, Karagounis LG, Terzis G, Jamurtas AZ, Spengos K, Tsoukas D, Chatzinikolaou A, Mandalidis D, Stefanetti RJ, Papassotiriou I, Athanasopoulos S, Hawley JA, Russell AP, Fatouros IG
- Issue date: 2013 Jul
- Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans.
- Authors: Morrison D, Hughes J, Della Gatta PA, Mason S, Lamon S, Russell AP, Wadley GD
- Issue date: 2015 Dec
- Avenanthramide supplementation attenuates eccentric exercise-inflicted blood inflammatory markers in women.
- Authors: Koenig RT, Dickman JR, Kang CH, Zhang T, Chu YF, Ji LL
- Issue date: 2016 Jan
- Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial.
- Authors: Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H
- Issue date: 2017
- Protein ingestion preserves proteasome activity during intense aseptic inflammation and facilitates skeletal muscle recovery in humans.
- Authors: Draganidis D, Chondrogianni N, Chatzinikolaou A, Terzis G, Karagounis LG, Sovatzidis A, Avloniti A, Lefaki M, Protopapa M, Deli CK, Papanikolaou K, Jamurtas AZ, Fatouros IG
- Issue date: 2017 Aug