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dc.contributor.authorPoulianiti, Konstantina P
dc.contributor.authorKaltsatou, Antonia
dc.contributor.authorMitrou, Georgia I
dc.contributor.authorJamurtas, Athanasios Z
dc.contributor.authorKoutedakis, Yiannis
dc.contributor.authorMaridaki, Maria
dc.contributor.authorStefanidis, Ioannis
dc.contributor.authorSakkas, Giorgos K
dc.contributor.authorKaratzaferi, Christina
dc.date.accessioned2017-10-11T15:22:48Z
dc.date.available2017-10-11T15:22:48Z
dc.date.issued2016-06-07
dc.identifier.citationPoulianiti, K. P., Kaltsatou, A., Mitrou, G. I. et al. (2016) Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8598253, 19 pages, 2016. https://doi.org/10.1155/2016/8598253.
dc.identifier.issn1942-0900
dc.identifier.pmid27563376
dc.identifier.doi10.1155/2016/8598253
dc.identifier.urihttp://hdl.handle.net/2436/620757
dc.description.abstractPatients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.subject.meshAnimals
dc.subject.meshAntioxidants
dc.subject.meshHumans
dc.subject.meshKidney
dc.subject.meshLipid Peroxidation
dc.subject.meshOxidation-Reduction
dc.subject.meshOxidative Stress
dc.subject.meshPrognosis
dc.subject.meshProtein Carbonylation
dc.subject.meshReactive Oxygen Species
dc.subject.meshRenal Insufficiency, Chronic
dc.titleSystemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.
dc.typeJournal article
dc.identifier.journalOxidative medicine and cellular longevity
dc.date.accepted2016-06-07
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUOW111017YK2
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-10-11
dc.source.volume
dc.source.issue5
dc.source.beginpage1
dc.source.endpage19
refterms.dateFCD2018-10-19T08:41:03Z
refterms.versionFCDVoR
refterms.dateFOA2017-10-11T00:00:00Z
html.description.abstractPatients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.


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