Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsPoulianiti, Konstantina P
Mitrou, Georgia I
Jamurtas, Athanasios Z
Sakkas, Giorgos K
MetadataShow full item record
AbstractPatients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.
CitationPoulianiti, K. P., Kaltsatou, A., Mitrou, G. I. et al. (2016) Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8598253, 19 pages, 2016. https://doi.org/10.1155/2016/8598253.
PublisherHindawi Publishing Corporation
JournalOxidative medicine and cellular longevity
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
- Nuclear Respiratory Factor-1 (NRF-1) Gene Expression in Chronic Kidney Disease Patients Undergoing Hemodialysis and Mitochondrial Oxidative Dysregulation.
- Authors: Hashad D, Elgohry I, Dwedar F
- Issue date: 2016 Nov 1
- Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease.
- Authors: Signorini L, Granata S, Lupo A, Zaza G
- Issue date: 2017 Jul 10
- The balance of powers: Redox regulation of fibrogenic pathways in kidney injury.
- Authors: Okamura DM, Pennathur S
- Issue date: 2015 Dec
- Oxidant Mechanisms in Renal Injury and Disease.
- Authors: Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS
- Issue date: 2016 Jul 20
- Overproduction of reactive oxygen species in end-stage renal disease patients: a potential component of hemodialysis-associated inflammation.
- Authors: Morena M, Delbosc S, Dupuy AM, Canaud B, Cristol JP
- Issue date: 2005 Jan