Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review.
Authors
Poulianiti, Konstantina PKaltsatou, Antonia
Mitrou, Georgia I
Jamurtas, Athanasios Z
Koutedakis, Yiannis
Maridaki, Maria
Stefanidis, Ioannis
Sakkas, Giorgos K
Karatzaferi, Christina
Issue Date
2016-06-07
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Show full item recordAbstract
Patients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage. However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty-nine studies met the inclusion criteria and were reviewed. Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense. However, other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.Citation
Poulianiti, K. P., Kaltsatou, A., Mitrou, G. I. et al. (2016) Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8598253, 19 pages, 2016. https://doi.org/10.1155/2016/8598253.Publisher
HindawiJournal
Oxidative medicine and cellular longevityPubMed ID
27563376Type
Journal articleLanguage
enISSN
1942-0900ae974a485f413a2113503eed53cd6c53
10.1155/2016/8598253
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- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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