Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)
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AbstractAnimal models are known not to predict human responses well, in general. However, we have been able to demonstrate that, for a series of non-steroidal anti-inflammatory drugs that are or were in clinical use, the incorporation of two simple physicochemical properties results in excellent correlations between human and rodent potencies for anti-inflammatory, analgesic and anti-pyretic activities. This has the potential to allow the use of historical data to improve drug development.
CitationDearden, J. C., Hewitt, M., Bresnen, G. M., Gregg, C. N. (2017) 'Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)' SAR and QSAR in Environmental Research. 28 (7): pp. 557
PublisherTaylor & Francis
JournalSAR and QSAR in Environmental Research