Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)
Abstract
Animal models are known not to predict human responses well, in general. However, we have been able to demonstrate that, for a series of non-steroidal anti-inflammatory drugs that are or were in clinical use, the incorporation of two simple physicochemical properties results in excellent correlations between human and rodent potencies for anti-inflammatory, analgesic and anti-pyretic activities. This has the potential to allow the use of historical data to improve drug development.Citation
Dearden, J. C., Hewitt, M., Bresnen, G. M., Gregg, C. N. (2017) 'Improved correlation between animal and human potency of non-steroidal anti-inflammatory drugs using quantitative structure–activity relationships (QSARs)' SAR and QSAR in Environmental Research. 28 (7): pp. 557Publisher
Taylor & FrancisJournal
SAR and QSAR in Environmental ResearchAdditional Links
https://www.tandfonline.com/doi/full/10.1080/1062936X.2017.1351391Type
Journal articleLanguage
enISSN
1062-936Xae974a485f413a2113503eed53cd6c53
10.1080/1062936X.2017.1351391