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dc.contributor.authorRadecka, Iza
dc.contributor.authorKwiecień, Iwona
dc.contributor.authorKowalczuk, Marek
dc.contributor.authorJelonek, Katarzyna
dc.contributor.authorOrchel, Arkadiusz
dc.contributor.authorAdamus, Grażyna
dc.date.accessioned2017-06-22T13:47:54Z
dc.date.available2017-06-22T13:47:54Z
dc.date.issued2017-09
dc.identifier.citationKwiecień I., Radecka I., Kowalczuk M., Jelonek K., Orchel A., Adamus G. (2017) 'The synthesis and structural characterization of graft copolymers composed of γ-PGA backbone and oligoesters pendant chains', Journal of The American Society for Mass Spectrometry, 28 (10) pp. 2223-2234. doi: 10.1007/s13361-017-1731-y.
dc.identifier.issn1044-0305
dc.identifier.urihttp://hdl.handle.net/2436/620524
dc.description.abstractThe novel copolymers composed of poly-γ-glutamic acid (γ-PGA) and oligoesters have been developed. The structures of the obtained copolymers including variety of end groups were determined at the molecular level with the aid of electrospray ionization multistage mass spectrometry (ESI-MSn). The fragmentation experiment performed for the selected sodium adducts of the copolymers confirmed that the developed methods lead to the formation of graft copolymers composed of poly-γ-glutamic acid (γ-PGA) backbone and oligoesters pendant chains. Moreover, it was established that fragmentation of selected sodium adducts of graft copolymers proceeded via random breakage of amide bonds along the backbone and ester bonds of the oligoesters pendant chains. Considering potential applications of the synthesized copolymers in the area of biomaterials, the hydrolytic degradation under laboratory conditions and in vitro cytotoxicity tests were performed. The ESI-MSn technique applied in this study has been proven to be a useful tool in structural studies of novel graft copolymers as well as their degradation products.
dc.description.sponsorshipThis work was supported by the Polish National Science Centre (Decision No DEC-2013/11/N/ST5/01364)
dc.language.isoen
dc.publisherJASMS
dc.relation.urlhttps://link.springer.com/journal/volumesAndIssues/13361
dc.subjectbiopolymers
dc.subjectgraft copolymers
dc.subjectpolyamides
dc.subjectpolyesters
dc.subjectmass spectrometry
dc.titleThe synthesis and structural characterization of graft copolymers composed of γ-PGA backbone and oligoesters pendant chains
dc.typeJournal article
dc.identifier.journalJournal of The American Society for Mass Spectrometry
dc.date.accepted2017-05
rioxxterms.funderThis work was supported by the Polish National Science Centre (Decision No DEC-2013/11/N/ST5/01364)
rioxxterms.identifier.projectUoW220617IR
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2018-09-01
refterms.dateFCD2018-10-19T09:23:24Z
refterms.versionFCDAM


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