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dc.contributor.authorKwiecien, Michal
dc.contributor.authorKwiecien, Iwona
dc.contributor.authorRadecka, Iza
dc.contributor.authorKannappan, Vinodh
dc.contributor.authorMorris, Mark R.
dc.contributor.authorAdamus, Grazyna
dc.date.accessioned2017-06-22T11:23:02Z
dc.date.available2017-06-22T11:23:02Z
dc.date.issued2017-04-10
dc.identifier.citation(2017) 'Biocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments - synthesis and characterization' 7 (33) 20469 RSC Advances
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/C6RA27980E
dc.identifier.urihttp://hdl.handle.net/2436/620523
dc.description.abstractA convenient synthetic route of poly(3HB-co-3HH-co-SEB) terpolyesters has been reported. The developed protocol consists of two steps; poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHx) oligoesterdiols were synthesized via selective reduction of biopolyesters and then via their polycondensation with sebacoyl chloride the biodegradable terpolyesters, poly(3HB-co-3HH-co-SEB), were obtained. The structure of the obtained terpolyesters was established by NMR analysis supported by mass spectrometry. Modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by incorporating units derived from sebacic acid into its chains resulted in terpolyesters with better physico-chemical properties than the starting PHBHx biopolyester. These new polyester materials have greater thermal stability than the starting biopolyester. Furthermore, the introduction of sebacic acid units to a polyester chain leads to the reduction of the glass transition temperatures of the materials and reduces the required processing temperature. A preliminary study confirmed that poly(3HB-co-3HH-co-SEB) terpolyesters can be used to create scaffolds for cell cultures in the form of a three-dimensional spatial structure. Moreover, a toxicity test of the obtained terpolyester carried out on human cells demonstrated that the novel terpolyester is not toxic to human cells in vitro.
dc.language.isoen
dc.publisherThe Royal Society of Chemistry
dc.relation.urlhttp://xlink.rsc.org/?DOI=C6RA27980E
dc.subjectBiocompatible terpolyesters
dc.subjectpolyhydroxyalkanoate
dc.subjectsebacic acid
dc.titleBiocompatible terpolyesters containing polyhydroxyalkanoate and sebacic acid structural segments - synthesis and characterization
dc.typeJournal article
dc.identifier.journalRSC Advances
dc.date.accepted2017-03-29
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectDEC-2013/11/B/ST5/02222
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2017-06-22
dc.source.volume7
dc.source.issue33
refterms.dateFCD2018-10-19T09:28:38Z
refterms.versionFCDAM
refterms.dateFOA2018-08-21T14:01:56Z
html.description.abstractA convenient synthetic route of poly(3HB-co-3HH-co-SEB) terpolyesters has been reported. The developed protocol consists of two steps; poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHx) oligoesterdiols were synthesized via selective reduction of biopolyesters and then via their polycondensation with sebacoyl chloride the biodegradable terpolyesters, poly(3HB-co-3HH-co-SEB), were obtained. The structure of the obtained terpolyesters was established by NMR analysis supported by mass spectrometry. Modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by incorporating units derived from sebacic acid into its chains resulted in terpolyesters with better physico-chemical properties than the starting PHBHx biopolyester. These new polyester materials have greater thermal stability than the starting biopolyester. Furthermore, the introduction of sebacic acid units to a polyester chain leads to the reduction of the glass transition temperatures of the materials and reduces the required processing temperature. A preliminary study confirmed that poly(3HB-co-3HH-co-SEB) terpolyesters can be used to create scaffolds for cell cultures in the form of a three-dimensional spatial structure. Moreover, a toxicity test of the obtained terpolyester carried out on human cells demonstrated that the novel terpolyester is not toxic to human cells in vitro.


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