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dc.contributor.authorKhalil, Ibrahim
dc.contributor.authorBurns, Alan
dc.contributor.authorRadecka, Iza
dc.contributor.authorKowalczuk, Marek
dc.contributor.authorKhalaf, Tamara
dc.contributor.authorAdamus, Grazyna
dc.contributor.authorJohnston, Brian
dc.contributor.authorKhechara, Martin
dc.date.accessioned2017-02-07T14:36:22Z
dc.date.available2017-02-07T14:36:22Z
dc.date.issued2017-02-02
dc.identifier.citationKhalil IR., Burns AT., Radecka I., Kowalczuk M., Khalaf T., Adamus G., Johnston B., Khechara MP. (2017) 'Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications', International Journal of Molecular Sciences, 18 (2) 313, doi: 10.3390/ijms18020313
dc.identifier.issn1661-6596
dc.identifier.doi10.3390/ijms18020313
dc.identifier.urihttp://hdl.handle.net/2436/620372
dc.description.abstractAbstract: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.
dc.description.sponsorshipIraqi cultural attaché
dc.language.isoen
dc.relation.urlhttp://www.mdpi.com/1422-0067/18/2/313
dc.subjectγ-PGA
dc.subjectantimicrobial
dc.subjectdrug delivery system
dc.titleBacterial-derived Polymer Poly-y-Glutamic Acid (y-PGA)-based micro/nanoparticles as a delivery system for antimicrobials and other biomedical applications
dc.typeJournal article
dc.identifier.journalInternational Journal of Molecular Sciences
dc.date.accepted2017-01-18
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUoW070217IR
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2017-02-07
dc.source.volume18
dc.source.issue2
refterms.dateFCD2018-10-19T09:23:24Z
refterms.versionFCDVoR
refterms.dateFOA2017-02-07T00:00:00Z
html.description.abstractAbstract: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.


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