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    LDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men.

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    Authors
    O'donovan, G
    McEneny, J
    Kearney, E M
    Owen, A
    Nevill, Alan M.
    Woolf-May, K
    Bird, S R
    Issue Date
    2007-08
    
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    Abstract
    Habitual exercisers enjoy considerable protection from coronary heart disease (CHD). Often, however, only modest differences in traditional CHD risk factors are apparent between habitual exercisers and their sedentary counterparts. For this reason, there is increasing interest in novel predictors of CHD, such as a preponderance of small, dense low-density lipoprotein (LDL) particles. Polyacrylamide gel electrophoresis was used to separate lipoprotein subfractions in 32 lean exercisers, 36 lean sedentary men and 21 obese sedentary men aged 30 - 45 years. Well-validated equations were used to determine LDL concentration and peak particle diameter. Waist girth was used to identify lean (< 100 cm) and obese (>or= 100 cm) individuals. LDL concentration was lower in lean exercisers than in lean sedentary men (2.64 +/- 0.44 vs. 3.76 +/- 0.79 mmol . l (-1), p < 0.001), suggesting that habitual exercise influences this risk factor. In contrast, there were no significant differences in LDL peak particle diameter between lean exercisers, lean sedentary men and obese sedentary men (27.92 +/- 0.67, 28.09 +/- 0.62 and 27.77 +/- 0.77 nm, respectively). In multiple linear regression analysis, triglyceride concentration was the only significant predictor of LDL PPD. These data suggest that habitual exercise influences LDL concentration but does not influence LDL particle size in men aged 30 - 45 years.
    Citation
    LDL particle size in habitual exercisers, lean sedentary men and abdominally obese sedentary men. 2007, 28 (8):644-9 Int J Sports Med
    Publisher
    Thieme
    Journal
    International journal of sports medicine
    URI
    http://hdl.handle.net/2436/620364
    DOI
    10.1055/s-2007-964892
    PubMed ID
    17436197
    Type
    Journal article
    Language
    en
    ISSN
    0172-4622
    0172-4622
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-2007-964892
    Scopus Count
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