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dc.contributor.authorGupta, Abhishek
dc.contributor.authorLow, Wan Li
dc.contributor.authorBritland, Stephen T
dc.contributor.authorMohd Amin, Mohd Cairul Iqbal
dc.contributor.authorMartin, Claire
dc.contributor.authorRadecka, Iza
dc.date.accessioned2016-12-19T16:03:07Z
dc.date.available2016-12-19T16:03:07Z
dc.date.issued2016-10-26
dc.identifier.citationGupta A., Low WL., Radecka I., Britland ST., Mohd Amin MC, Martin C. (2016) 'Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels, Journal of Microencapsulation, 33(8) pp. 725-734 doi: 10.1080/02652048.2016.1253796
dc.identifier.issn0265-2048
dc.identifier.pmid27781557
dc.identifier.doi10.1080/02652048.2016.1253796
dc.identifier.urihttp://hdl.handle.net/2436/620316
dc.description.abstractWounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.
dc.language.isoen
dc.publisherTaylor & Francis Online
dc.relation.urlhttp://www.tandfonline.com/doi/abs/10.1080/02652048.2016.1253796?journalCode=imnc20
dc.subjectAntimicrobial
dc.subjectbacterial cellulose
dc.subjecthydrogel
dc.subjectsilver
dc.subjectsilver zeolite
dc.titleCharacterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.
dc.typeJournal article
dc.identifier.journalJournal of Microencapsulation
dc.date.accepted2016-10-17
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectUoW191216IR
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2017-11-30
dc.source.volume33
dc.source.issue8
dc.source.beginpage725
dc.source.endpage734
refterms.dateFCD2018-10-19T09:24:43Z
refterms.versionFCDAM
refterms.dateFOA2018-08-08T12:10:28Z
html.description.abstractWounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.


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