Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.
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Low, Wan Li
Britland, Stephen T
Mohd Amin, Mohd Cairul Iqbal
MetadataShow full item record
AbstractWounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.
CitationGupta A., Low WL., Radecka I., Britland ST., Mohd Amin MC, Martin C. (2016) 'Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels, Journal of Microencapsulation, 33 (8) pp. 725-734 doi: 10.1080/02652048.2016.1253796
PublisherTaylor & Francis Online
JournalJournal of Microencapsulation
DescriptionThis is an accepted manuscript of an article published by Taylor & Francis in Journal of Microencapsulation on 28/11/2016, available online: https://doi.org/10.1080/02652048.2016.1253796 The accepted version of the publication may differ from the final published version.
The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
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