Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels.
Authors
Gupta, AbhishekLow, Wan Li
Britland, Stephen T
Mohd Amin, Mohd Cairul Iqbal
Martin, Claire
Radecka, Iza
Issue Date
2016-11-28
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Show full item recordAbstract
Wounds that remain in the inflammatory phase for a prolonged period of time are likely to be colonised and infected by a range of commensal and pathogenic microorganisms. Treatment associated with these types of wounds mainly focuses on controlling infection and providing an optimum environment capable of facilitating re-epithelialisation, thus promoting wound healing. Hydrogels have attracted vast interest as moist wound-responsive dressing materials. In the current study, biosynthetic bacterial cellulose hydrogels synthesised by Gluconacetobacter xylinus and subsequently loaded with silver were characterised and investigated for their antimicrobial activity against two representative wound infecting pathogens, namely S. aureus and P. aeruginosa. Silver nitrate and silver zeolite provided the source of silver and loading parameters were optimised based on experimental findings. The results indicate that both AgNO3 and AgZ loaded biosynthetic hydrogels possess antimicrobial activity (p < .05) against both S. aureus and P. aeruginosa and may therefore be suitable for wound management applications.Citation
Gupta A., Low WL., Radecka I., Britland ST., Mohd Amin MC, Martin C. (2016) 'Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels, Journal of Microencapsulation, 33 (8) pp. 725-734 doi: 10.1080/02652048.2016.1253796Publisher
Taylor & Francis OnlineJournal
Journal of MicroencapsulationPubMed ID
27781557Additional Links
http://www.tandfonline.com/doi/abs/10.1080/02652048.2016.1253796?journalCode=imnc20Type
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by Taylor & Francis in Journal of Microencapsulation on 28/11/2016, available online: https://doi.org/10.1080/02652048.2016.1253796 The accepted version of the publication may differ from the final published version.ISSN
0265-2048ae974a485f413a2113503eed53cd6c53
10.1080/02652048.2016.1253796
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The following licence applies to the copyright and re-use of this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/
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