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dc.contributor.authorKwiecień, Iwona
dc.contributor.authorKwiecień, Michał
dc.contributor.authorAdamus, Grażyna
dc.contributor.authorRadecka, Iza
dc.date.accessioned2016-11-21T12:33:44Z
dc.date.available2016-11-21T12:33:44Z
dc.date.issued2016-04-25
dc.identifier.citationKwiecień, I., Kwiecień, M., Adamus, G., and Radecka, I. (2016) 'Synthesis and Structural Characterization of Bioactive PHA and γ-PGA Oligomers for Potential Applications as a Delivery System', Materials, 9 (5) doi: 10.3390/ma9050307
dc.identifier.issn1996-1944
dc.identifier.doi10.3390/ma9050307
dc.identifier.urihttp://hdl.handle.net/2436/620289
dc.description.abstractThe (trans)esterification reaction of bacterial biopolymers with a selected bioactive compound with a hydroxyl group was applied as a convenient method for obtaining conjugates of such compound. Tyrosol, a naturally occurring phenolic compound, was selected as a model of a bioactive compound with a hydroxyl group. Selected biodegradable polyester and polyamide, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) and poly-γ-glutamic acid (γ-PGA), respectively, were used. The (trans)esterification reactions were carried out in melt mediated by 4-toluenesulfonic acid monohydrate. The structures of (trans)esterification products were established at the molecular level with the aid of ESI-MS2 (electrospray ionization tandem mass spectrometry) and/or 1H NMR (nuclear magnetic resonance) techniques. Performed analyses confirmed that the developed method leads to the formation of conjugates in which bioactive compounds are covalently bonded to biopolymer chains. The amount of covalently bonded bioactive compounds in the resulting conjugates depends on the type of biopolymers applied in synthesis.
dc.language.isoen
dc.publisherMDPI - Open Access Publishing
dc.relation.urlhttp://www.mdpi.com/1996-1944/9/5/307
dc.subjectbiodegradable polymers
dc.subjectpolyhydroxyalkanoates
dc.subjectP(3HB-co-4HB)
dc.subjectpoly-ƴ-glutamic
dc.subjectƴ-PGA
dc.subjectconjugates
dc.subjecttyrosol
dc.subjectmass spectrometry
dc.titleSynthesis and structural characterization of bioactive PHA and γ-PGA oligomers for potential applications as a delivery system
dc.typeJournal article
dc.identifier.journalMaterials
dc.date.accepted2016-04-19
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectDTI (BIOAD) TP/5/REG/6/I/H0669A
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2016-11-21
dc.source.volume9
dc.source.issue5
refterms.dateFCD2018-10-19T09:23:24Z
refterms.versionFCDVoR
refterms.dateFOA2016-11-21T00:00:00Z
html.description.abstractThe (trans)esterification reaction of bacterial biopolymers with a selected bioactive compound with a hydroxyl group was applied as a convenient method for obtaining conjugates of such compound. Tyrosol, a naturally occurring phenolic compound, was selected as a model of a bioactive compound with a hydroxyl group. Selected biodegradable polyester and polyamide, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) and poly-γ-glutamic acid (γ-PGA), respectively, were used. The (trans)esterification reactions were carried out in melt mediated by 4-toluenesulfonic acid monohydrate. The structures of (trans)esterification products were established at the molecular level with the aid of ESI-MS2 (electrospray ionization tandem mass spectrometry) and/or 1H NMR (nuclear magnetic resonance) techniques. Performed analyses confirmed that the developed method leads to the formation of conjugates in which bioactive compounds are covalently bonded to biopolymer chains. The amount of covalently bonded bioactive compounds in the resulting conjugates depends on the type of biopolymers applied in synthesis.


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