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dc.contributor.authorSchiller, T.L.
dc.contributor.authorBlakey, I.
dc.contributor.authorFredericks, P.M.
dc.contributor.authorKeddie, Daniel
dc.date.accessioned2016-11-04T14:23:29Z
dc.date.available2016-11-04T14:23:29Z
dc.date.issued2016-09-15
dc.identifier.citation'Surface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays', European Polymer Journal, 87 . pp. 508-518. doi:10.1016/j.eurpolymj.2016.08.032
dc.identifier.issn0014-3057
dc.identifier.doi10.1016/j.eurpolymj.2016.08.032
dc.identifier.urihttp://hdl.handle.net/2436/620258
dc.description.abstractThe preparation of biotinylated, self-assembled polymer stabilized gold nanoparticle hybrids encoded with a SERS active compound is described. The polymers used for nanoparticle stabilization are carefully designed for this purpose and are synthesized by the RAFT polymerization process, as the thiocarbonylthio end group provides a functional handle for anchoring the polymers to the gold surface. Functionalised biotin moieties are attached to the hybrid nanoparticles via Cu-catalyzed azide-alkyne cycloaddition. Binding of the biotinylated hybrid nanoparticles to streptavidin was confirmed by nanoparticle detection and identification by the SERS spectrum of the surface-bound SERS active compound, quinolinethiol. This investigation includes the requisites that constitute a bioassay, demonstrating the potential of polymer-coated hybrid nanoparticles for this purpose.
dc.description.sponsorshipAustralian Reasearch Council
dc.language.isoen
dc.publisherElsevier
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014305716309880
dc.subjectSERS
dc.subjectHybrid polymer-gold nanoparticles
dc.subjectBioassays
dc.subjectRAFT polymerization
dc.titleSurface-enhanced Raman encoded polymer stabilized gold nanoparticles: Demonstration of potential for use in bioassays
dc.typeJournal article
dc.identifier.journalEuropean Polymer Journal
dc.date.accepted2016-08-31
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.project041116DK
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2018-03-31
dc.source.volume87
dc.source.beginpage508
dc.source.endpage518
refterms.dateFCD2018-10-19T09:24:43Z
refterms.versionFCDAM
refterms.dateFOA2018-03-31T00:00:00Z
atmire.accessrights
html.description.abstractThe preparation of biotinylated, self-assembled polymer stabilized gold nanoparticle hybrids encoded with a SERS active compound is described. The polymers used for nanoparticle stabilization are carefully designed for this purpose and are synthesized by the RAFT polymerization process, as the thiocarbonylthio end group provides a functional handle for anchoring the polymers to the gold surface. Functionalised biotin moieties are attached to the hybrid nanoparticles via Cu-catalyzed azide-alkyne cycloaddition. Binding of the biotinylated hybrid nanoparticles to streptavidin was confirmed by nanoparticle detection and identification by the SERS spectrum of the surface-bound SERS active compound, quinolinethiol. This investigation includes the requisites that constitute a bioassay, demonstrating the potential of polymer-coated hybrid nanoparticles for this purpose.


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