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dc.contributor.authorAdebisi, Adeola O.
dc.contributor.authorHussain, Tariq
dc.contributor.authorAl-Hamidi, Hiba
dc.contributor.authorNokhodchi, Ali
dc.contributor.authorConway, Barbara R.
dc.contributor.authorAsare-Addo, Kofi
dc.contributor.authorKaialy, Waseem
dc.date.accessioned2016-07-22T13:42:57Z
dc.date.available2016-07-22T13:42:57Z
dc.date.issued2016-07-16
dc.identifier.citationAdebisi AO., Kaialy W., Hussain T., Al-Hamidi H., Nokhodchi A., Conway BR., Asare-Addo K. (2016) 'Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions', Colloids and Surfaces B: Biointerfaces 146, p. 841-851
dc.identifier.issn0927-7765
dc.identifier.doi10.1016/j.colsurfb.2016.07.032
dc.identifier.urihttp://hdl.handle.net/2436/617378
dc.description.abstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging were also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM. XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 μm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (−3.8 versus 0.5 nC/g for untreated material and −7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1–0.3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.
dc.language.isoen
dc.publisherElsevier
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0927776516305343
dc.subjectSolid dispersions
dc.subjectPiroxicam
dc.subjectD-glucosamine HCl
dc.subjectDissolution
dc.subjectElectrostatics
dc.subjectSpray drying
dc.titleSolid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions
dc.typeJournal article
dc.identifier.journalColloids and Surfaces B: Biointerfaces
dc.date.accepted2016-07-14
rioxxterms.funderUniversity of Wolverhampton
rioxxterms.identifier.projectInternal
rioxxterms.versionAM
rioxxterms.licenseref.urihttps://creativecommons.org/CC BY-NC-ND 4.0
rioxxterms.licenseref.startdate2017-07-16
dc.source.volume146
dc.source.beginpage841
dc.source.endpage851
refterms.dateFCD2018-10-19T09:28:38Z
refterms.versionFCDAM
refterms.dateFOA2017-07-13T00:00:00Z


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