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    Ionically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications

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    Authors
    Kenward, M.A.
    Amin, Mohd
    Martin, Claire
    Low, Wan Li
    Issue Date
    2016-03-01
    
    Metadata
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    Abstract
    The emerging problems posed by antibiotic resistance complicate the treatment regime required for wound infections and are driving the need to develop more effective methods of wound management. There is growing interest in the use of alternative, broad spectrum, pre-antibiotic antimicrobial agents such as essential oils (e.g., tea tree oil, TTO) and metal ions (e.g., silver, Ag+). Both TTO and Ag+ have broad spectrum antimicrobial activity and act on multiple target sites, hence reducing the likelihood of developing resistance. Combining such agents with responsive, controlled release delivery systems such as hydrogels may enhance microbiocidal activity and promote wound healing. The advantages of using chitosan to formulate the hydrogels include its biocompatible, mucoadhesive and controlled release properties. In this study, hydrogels loaded with TTO and Ag+ exhibited antimicrobial activity against P. aeruginosa, S. aureus and C. albicans. Combining TTO and Ag+ into the hydrogel further improved antimicrobial activity by lowering the effective concentrations required, respectively. This has obvious advantages for reducing the potential toxic effects on the healthy tissues surrounding the wound. These studies highlight the feasibility of delivering lower effective concentrations of antimicrobial agents such as TTO and Ag+ in ionically crosslinked chitosan hydrogels to treat common wound-infecting pathogens.
    Citation
    Ionically Crosslinked Chitosan Hydrogels for the Controlled Release of Antimicrobial Essential Oils and Metal Ions for Wound Management Applications 2016, 3 (1):8 Medicines
    Publisher
    MDPI AG, Basel, Switzerland
    Journal
    Medicines
    URI
    http://hdl.handle.net/2436/614074
    DOI
    10.3390/medicines3010008
    Additional Links
    http://www.mdpi.com/2305-6320/3/1/8
    Type
    Journal article
    Language
    en
    ISSN
    2305-6320
    ae974a485f413a2113503eed53cd6c53
    10.3390/medicines3010008
    Scopus Count
    Collections
    Research Institute in Healthcare Science

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