Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans
Abstract
Liposomes are biocompatible, biodegradable, controlled delivery systems with the ability to encapsulate both lipophilic and hydrophilic compounds, including metal ions. Liposome encapsulated Ag(+) (lipo-Ag(+)), prepared by reverse-phase evaporation, was used as a controlled delivery system against Candida albicans. Characterisation of the lipo-Ag(+) indicated that the multilamellar vesicles with diameters ranging between ≈ 0.5 and 5.0 μm showed potential as a controlled delivery system to consistently deliver Ag(+) to C. albicans. Results from inductively coupled plasma (ICP) analysis showed higher association of cell bound Ag(+) at 15 mins post exposure when compared to unencapsulated Ag(+). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate detrimental effects of Ag(+) on C. albicans cell structure. These effects along with the ICP results also correlate with previously reported time kill experiment observations.Citation
Low et al. (2016) Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans. Journal of Microencapsulation, 33 (2), pp. 146-52.Publisher
Taylor & FrancisJournal
Journal of MicroencapsulationPubMed ID
26786597Type
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by Taylor & Francis in Journal of Microencapsulation on 20/01/2016, available online: https://doi.org/10.3109/02652048.2015.1134692 The accepted version of the publication may differ from the final published version.ISSN
1464-5246ae974a485f413a2113503eed53cd6c53
10.3109/02652048.2015.1134692