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dc.contributor.authorLow, Wan-Li
dc.contributor.authorKenward, Ken
dc.contributor.authorBritland, Stephen T
dc.contributor.authorAmin, Mohd Cim
dc.contributor.authorMartin, Claire
dc.date.accessioned2016-06-10T13:08:53Zen
dc.date.available2016-06-10T13:08:53Zen
dc.date.issued2016-05-05
dc.identifier.citationLow, W., Kenward, K., Britland, ST., Amin, MC., Martin, C. (2016) 'Essential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver', International Wound Journal, 14(2) pp. 369-384. doi: 10.1111/iwj.12611
dc.identifier.issn1742-4801
dc.identifier.pmid27146784
dc.identifier.doi10.1111/iwj.12611
dc.identifier.urihttp://hdl.handle.net/2436/612518
dc.description.abstractThe increasing occurrence of hospital-acquired infections and the emerging problems posed by antibiotic-resistant microbial strains have both contributed to the escalating cost of treatment. The presence of infection at the wound site can potentially stall the healing process at the inflammatory stage, leading to the development of a chronic wound. Traditional wound treatment regimes can no longer cope with the complications posed by antibiotic-resistant strains; hence, there is a need to explore the use of alternative antimicrobial agents. Pre-antibiotic compounds, including heavy metal ions and essential oils, have been re-investigated for their potential use as effective antimicrobial agents. Essential oils have potent antimicrobial, antifungal, antiviral, anti-inflammatory, antioxidant and other beneficial therapeutic properties. Similarly, heavy metal ions have also been used as disinfecting agents because of their broad spectrum activities. Both of these alternative antimicrobials interact with many different intracellular components, thereby resulting in the disruption of vital cell functions and eventually cell death. This review will discuss the application of essential oils and heavy metal ions, particularly tea tree oil and silver ions, as alternative antimicrobial agents for the treatment of chronic, infected wounds.
dc.languageENG
dc.language.isoen
dc.publisherJohn Wiley & Sons Ltd and Medicalhelplines.com Inc.
dc.subjectAntimicrobial
dc.subjectSilver
dc.subjectTea tree oil
dc.subjectWound infection
dc.titleEssential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver.
dc.typeJournal article
dc.identifier.journalInternational Wound Journal
dc.date.accepted2016-04-19
rioxxterms.funderInternal
rioxxterms.identifier.projectUoW040816WLL
rioxxterms.versionAuthor's accepted manuscript
rioxxterms.licenseref.urihttps
rioxxterms.licenseref.startdate2016-08-042017-05-04
refterms.dateFOA2017-05-04T00:00:00Z
html.description.abstractThe increasing occurrence of hospital-acquired infections and the emerging problems posed by antibiotic-resistant microbial strains have both contributed to the escalating cost of treatment. The presence of infection at the wound site can potentially stall the healing process at the inflammatory stage, leading to the development of a chronic wound. Traditional wound treatment regimes can no longer cope with the complications posed by antibiotic-resistant strains; hence, there is a need to explore the use of alternative antimicrobial agents. Pre-antibiotic compounds, including heavy metal ions and essential oils, have been re-investigated for their potential use as effective antimicrobial agents. Essential oils have potent antimicrobial, antifungal, antiviral, anti-inflammatory, antioxidant and other beneficial therapeutic properties. Similarly, heavy metal ions have also been used as disinfecting agents because of their broad spectrum activities. Both of these alternative antimicrobials interact with many different intracellular components, thereby resulting in the disruption of vital cell functions and eventually cell death. This review will discuss the application of essential oils and heavy metal ions, particularly tea tree oil and silver ions, as alternative antimicrobial agents for the treatment of chronic, infected wounds.


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