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    On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review

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    Authors
    Kaialy, Waseem
    Issue Date
    2016-06-05
    
    Metadata
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    Abstract
    Blending drug and carrier powders to produce homogeneous drug–carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug–carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation were also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.
    Citation
    On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation – a review 2016 Advances in Colloid and Interface Science
    Publisher
    Elsevier
    Journal
    Advances in Colloid and Interface Science
    URI
    http://hdl.handle.net/2436/612012
    DOI
    10.1016/j.cis.2016.05.014
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0001868616300756
    Type
    Journal article
    Language
    en
    ISSN
    0001-8686
    EISSN
    1873-3727
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cis.2016.05.014
    Scopus Count
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    Faculty of Science and Engineering

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