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dc.contributor.authorDunmore, Simon J
dc.contributor.authorBrown, James E P
dc.date.accessioned2016-06-06T10:56:31Zen
dc.date.available2016-06-06T10:56:31Zen
dc.date.issued2012-09
dc.identifier.citationThe role of adipokines in β-cell failure of type 2 diabetes. 2013, 216 (1):T37-45 J. Endocrinol.
dc.identifier.issn1479-6805
dc.identifier.pmid22991412
dc.identifier.doi10.1530/JOE-12-0278
dc.identifier.urihttp://hdl.handle.net/2436/611796
dc.description.abstractβ-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of β-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, tumour necrosis factor α, resistin, visfatin, dipeptidyl peptidase IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to β-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines, which act on the β-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on β-cells.
dc.language.isoen
dc.publisherBioscientifica
dc.subjectBeta-cell
dc.subjecttype 2 diabetes
dc.subjectadipokines
dc.subject.meshAdipokines
dc.subject.meshAdipose Tissue
dc.subject.meshAnimals
dc.subject.meshCytokines
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshDipeptidyl Peptidase 4
dc.subject.meshHumans
dc.subject.meshInsulin-Secreting Cells
dc.subject.meshIntercellular Signaling Peptides and Proteins
dc.subject.meshObesity
dc.subject.meshPancreas
dc.titleThe role of adipokines in β-cell failure of type 2 diabetes.
dc.typeJournal article
dc.identifier.journalThe Journal of endocrinology, 216 (1) T37-T45
html.description.abstractβ-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of β-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, tumour necrosis factor α, resistin, visfatin, dipeptidyl peptidase IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to β-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines, which act on the β-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on β-cells.


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