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    The role of adipokines in β-cell failure of type 2 diabetes.

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    Authors
    Dunmore, Simon J
    Brown, James E P
    Issue Date
    2012-09
    
    Metadata
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    Abstract
    β-Cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review, we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of β-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, tumour necrosis factor α, resistin, visfatin, dipeptidyl peptidase IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to β-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines, which act on the β-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on β-cells.
    Citation
    The role of adipokines in β-cell failure of type 2 diabetes. 2013, 216 (1):T37-45 J. Endocrinol.
    Publisher
    Bioscientifica
    Journal
    The Journal of endocrinology, 216 (1) T37-T45
    URI
    http://hdl.handle.net/2436/611796
    DOI
    10.1530/JOE-12-0278
    PubMed ID
    22991412
    Type
    Journal article
    Language
    en
    ISSN
    1479-6805
    ae974a485f413a2113503eed53cd6c53
    10.1530/JOE-12-0278
    Scopus Count
    Collections
    Faculty of Science and Engineering

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