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    A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation

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    Authors
    Kaialy, Waseem
    Issue Date
    2016-02-02
    
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    Abstract
    Pharmaceutical powders are typically insulators consisting of relatively small particles and thus they usually exhibit significant electrostatic charging behaviours. In the inhalation field, the measurement of electrostatic charge is an imperative stage during pharmaceutical formulation development. The electrostatic charge is affected by the interplay of many factors. This article reviews the factors affecting the electrostatic charging of pharmaceutical powders with a focus on dry powder inhalations. The influences of particle resistivity, size distribution, shape distribution, surface roughness, polymorphic form and hygroscopicity, as well as the effects of moisture uptake, environmental conditions, pharmaceutical processing (i.e., milling, sieving, spray drying and blending), and storage on the electrostatic charge behaviours of pharmaceuticals, with focus on inhalation powders, were reviewed. The influence of electrostatic charge on the performance of dry powder inhaler formulations in terms of drug content homogeneity, the passage of drug through the inhaler device, drug-carrier adhesion/detachment, and drug deposition on the respiratory airways were discussed. The understanding gained is crucial to improving the safety, quality, and efficiency of the pharmaceutical inhalation products.
    Citation
    Kaialy, W. (2016) 'A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation', 503 (1-2) pp. 262-76
    Publisher
    Elsevier
    Journal
    International Journal of Pharmaceutics
    URI
    http://hdl.handle.net/2436/605647
    DOI
    10.1016/j.ijpharm.2016.01.076
    PubMed ID
    26836710
    Type
    Journal article
    Language
    en
    ISSN
    1873-3476
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijpharm.2016.01.076
    Scopus Count
    Collections
    Faculty of Science and Engineering

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