• Admin Login
    View Item 
    •   Home
    • Faculty of Science and Engineering
    • Faculty of Science and Engineering
    • View Item
    •   Home
    • Faculty of Science and Engineering
    • Faculty of Science and Engineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    Kaialy, Waseem
    Adebisi, Adeola O.
    Hussain, Tariq
    Al-Hamidi, Hiba
    Nokhodchi, Ali
    Conway, Barbara R.
    Asare-Addo, Kofi
    Issue Date
    2016-02-06
    
    Metadata
    Show full item record
    Abstract
    One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during the grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM. These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied. Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures was examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and/or when increasing the percentage proportion of CBZ up to 30% w:w. This study helps to provide information about the handling of these formulations and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.
    Citation
    An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine 2016, 292:342 Powder Technology
    Publisher
    Elsevier
    Journal
    Powder Technology
    URI
    http://hdl.handle.net/2436/605498
    DOI
    10.1016/j.powtec.2016.02.008
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0032591016300493
    Type
    Journal article
    Language
    en
    ISSN
    00325910
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.powtec.2016.02.008
    Scopus Count
    Collections
    Faculty of Science and Engineering

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.