Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Metsios, George S
Veldhuijzen van Zanten, Jet J C S
Duda, Joan L
Rouse, Peter C
Kitas, George D
MetadataShow full item record
AbstractThe aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA.A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases.Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity.VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA.
CitationMetsios, GS and Koutedakis, Y and Veldhuijzen van Zanten, JJ and Stavropoulos-Kalinoglou, A and Vitalis, P and Duda, JL and Ntoumanis, N and Rouse, PC and Kitas, GD (2015) Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study. Rheumatology (Oxford), 54 (12). pp. 2215-2220. DOI: https://doi.org/10.1093/rheumatology/kev035
PublisherOxford Journals (OUP)
JournalRheumatology (Oxford, England)
- Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis.
- Authors: Metsios GS, Stavropoulos-Kalinoglou A, Panoulas VF, Wilson M, Nevill AM, Koutedakis Y, Kitas GD
- Issue date: 2009 Apr
- Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Veldhuijzen van Zanten JJ, Nightingale P, Kitas GD, Koutedakis Y
- Issue date: 2013 Nov
- Cardiorespiratory fitness and plasma homocysteine levels in adult males and females.
- Authors: Dankner R, Geulayov G, Farber N, Novikov I, Segev S, Sela BA
- Issue date: 2009 Feb
- Respiratory fitness, free living physical activity, and cardiovascular disease risk in older individuals: a doubly labeled water study.
- Authors: Dvorak RV, Tchernof A, Starling RD, Ades PA, DiPietro L, Poehlman ET
- Issue date: 2000 Mar
- The impact of cardiorespiratory fitness on classical cardiovascular disease risk factors in rheumatoid arthritis: a cross-sectional and longitudinal study.
- Authors: Cooney JK, Ahmad YA, Moore JP, Sandoo A, Thom JM
- Issue date: 2019 Oct