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    Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study

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    Authors
    Koutedakis, Yiannis
    Metsios, George S
    Veldhuijzen van Zanten, Jet J C S
    Stavropoulos-Kalinoglou, Antonis
    Vitalis, Panagiotis
    Duda, Joan L
    Ntoumanis, Nikos
    Rouse, Peter C
    Kitas, George D
    Issue Date
    2015-07-25
    
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    Abstract
    The aim of this study was to investigate the association of different physical fitness levels [assessed by the maximal oxygen uptake (VO2max) test] with cardiovascular disease (CVD) risk factors in patients with RA.A total of 150 RA patients were assessed for cardiorespiratory fitness with a VO2max test and, based on this, were split in three groups using the 33rd (18.1 ml/kg/min) and 66th (22.4 ml/kg/min) centiles. Classical and novel CVD risk factors [blood pressure, body fat, insulin resistance, cholesterol, triglycerides, high-density lipoprotein (HDL), physical activity, CRP, fibrinogen and white cell count], 10-year CVD risk, disease activity (DAS28) and severity (HAQ) were assessed in all cases.Mean VO2max for all RA patients was 20.9 (s.d. 5.7) ml/kg/min. The 10-year CVD risk (P = 0.003), systolic blood pressure (P = 0.039), HDL (P = 0.017), insulin resistance and body fat (both at P < 0.001), CRP (P = 0.005), white blood cell count (P = 0.015) and fibrinogen (P < 0.001) were significantly different between the VO2max tertiles favouring the group with the higher VO2max levels. In multivariate analyses of variance, VO2max was significantly associated with body fat (P < 0.001), HDL (P = 0.007), insulin resistance (P < 0.003) and 10-year CVD risk (P < 0.001), even after adjustment for DAS28, HAQ and physical activity.VO2max levels are alarmingly low in RA patients. Higher levels of VO2max are associated with a better cardiovascular profile in this population. Future studies need to focus on developing effective behavioural interventions to improve cardiorespiratory fitness in RA.
    Citation
    Metsios, GS and Koutedakis, Y and Veldhuijzen van Zanten, JJ and Stavropoulos-Kalinoglou, A and Vitalis, P and Duda, JL and Ntoumanis, N and Rouse, PC and Kitas, GD (2015) Cardiorespiratory fitness levels and their association with cardiovascular profile in patients with rheumatoid arthritis: a cross-sectional study. Rheumatology (Oxford), 54 (12). pp. 2215-2220. DOI: https://doi.org/10.1093/rheumatology/kev035
    Publisher
    Oxford Journals (OUP)
    Journal
    Rheumatology (Oxford, England)
    URI
    http://hdl.handle.net/2436/605291
    DOI
    10.1093/rheumatology/kev035
    PubMed ID
    26209790
    Additional Links
    http://europepmc.org/abstract/med/26209790
    Type
    Journal article
    Language
    en
    ISSN
    1462-0332
    ae974a485f413a2113503eed53cd6c53
    10.1093/rheumatology/kev035
    Scopus Count
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    Faculty of Education, Health and Wellbeing

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