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    Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications

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    Authors
    Bolton, Shawna N.
    Whitehead, Michael P.
    Dudhia, Jayesh
    Baldwin, Timothy C.
    Sutton, Raul
    Issue Date
    2015-07
    
    Metadata
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    Abstract
    This study investigated the postmortem molecular changes that articular cartilage undergoes following burial. Fresh pig trotters were interred in 30-cm-deep graves at two distinct locations exhibiting dissimilar soil environments for up to 42 days. Extracts of the metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joint cartilage from trotters disinterred weekly over 6 weeks were analyzed by Western blot against the monoclonal antibody 2-B-6 to assess aggrecan degradation. In both soil conditions, aggrecan degradation by-products of decreasing molecular size and complexity were observed up to 21 days postmortem. Degradation products were undetected after this time and coincided with MCP/MTP joint exposure to the soil environment. These results show that cartilage proteoglycans undergo an ordered molecular breakdown, the analysis of which may have forensic applications. This model may prove useful for use as a human model and for forensic investigations concerning crimes against animals and the mortality of endangered species.
    Citation
    Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications 2015, 60 (4):1061 Journal of Forensic Sciences
    Publisher
    Wiley
    Journal
    Journal of Forensic Sciences
    URI
    http://hdl.handle.net/2436/604095
    DOI
    10.1111/1556-4029.12764
    Additional Links
    http://doi.wiley.com/10.1111/1556-4029.12764
    Type
    Journal article
    Language
    en
    ISSN
    00221198
    ae974a485f413a2113503eed53cd6c53
    10.1111/1556-4029.12764
    Scopus Count
    Collections
    Faculty of Science and Engineering

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