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Circulating Sclerostin responses to acute weight and non weight bearing sport activity in pre adolescent malesJamurtas, Athanasios Z; Leontsini, Diamanda; Avloniti, Alexandra; Vlachopoulos, Dimitris; Stampoulis, Theodoros; Chatzinikolaou, Athanasios; Gracia-Marco, Luis; Ubago-Guisado, Esther; Makris, Konstantinos; Tournis, Symeon; et al. (Ovid Technologies (Wolters Kluwer Health), 2017-05-01)Mechanical loading, i.e. physical activity and/or exercise, promotes bone formation during growth. Sclerostin, a glycoprotein, mediates osteocytes' response to mechanical loading by inhibiting the Wnt/lf-catenin pathway thereby inhibiting bone formation.