• Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers

      Georgakouli, K; Manthou, E; Fatouros, IG; Georgoulias, P; Deli, CK; Koutedakis, Y; Theodorakis, Y; Jamurtas, AZ; Department of Physical Education and Sport Science, University of Thessaly, Karies, Trikala 42100, Greece; Institute of Human Performance and Rehabilitation, Centre for Research and Technology - Thessaly (CERETETH), Karies, Trikala 42100, Greece. Electronic address: kgeorgakouli@gmail.com. (Elsevier BV, 2017-12-02)
      © 2017 Elsevier Inc. Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. In a non-randomized within-subject design, 11 sedentary, heavily drinking men (age: 30.3 ± 3.5 years; BMI: 28.4 ± 0.86 kg/m2) participated first in a control condition for 4 weeks, and then in an intervention where they completed an 8-week supervised aerobic training program of moderate intensity (50–60% of the heart rate reserve). Blood samples were collected in the control condition (pre-, post-control) as well as before, during (week 4 of the training program), and after intervention (week 8 of the training program). Samples were analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), uric acid (UA), bilirubin, reduced glutathione (GSH), and catalase activity. No significant change in indices of redox status in the pre- and post-control was observed. Catalase activity increased (p < 0.05) after 8 weeks of intervention compared to week 4. GSH increased (p < 0.05) after 8 weeks of intervention compared to the control condition and to week 4 of intervention. TAC, UA, bilirubin, TBARS, and PC did not significantly change at any time point. Moreover, concentrations of GSH, TBARS, and catalase activity negatively correlated with alcohol consumption. In conclusion, an 8-week aerobic training program enhanced erythrocyte antioxidant status in heavy drinkers, indicating that aerobic training may attenuate pathological processes caused by alcohol-induced oxidative stress.
    • Human brown adipose tissue activity assessed via positron emission tomography/computed tomography is inversely associated with environmental temperature

      Georgakopoulos, A; Koutsikos, J; Krase, A; Nintou, E; Metaxas, M; Athanasiou, K; Georgoulias, P; Gkiata, P; Koutedakis, Y; Dinas, P; et al. (Springer, 2018-10)
      Introduction: Cold exposure increases brown adipose tissue (BAT) activity, which may lead to increased resting energy expenditure (REE) with beneficial effects on body composition. However, evidence on the impact of normal daily living environmental temperature (Tenv) on BAT activity is limited. In this study, we examined the impact of Tenv on BAT activity of healthy men.