• Cytokine storm and signaling pathways: pathogenesis of SARS‐CoV‐2 infection, managing and treatment strategies

      Kumar, Rajiv; Gulia, Kiran (Biomedical Research Network, 2021-05-03)
      Coronavirus disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to date, no novel treatment so far is available to cure it. Therefore, it is an urgent need to develop an effective treatment for the patients who are suffering from it. Naturally, when SARS-CoV-2 infection transpired, the nervous system of the body of the patient responds to it immediately by activating the immune cells that further triggered inflammation to counter it. In this fight, the cytokine storms originated in the host cells and it becomes life-threatening and finally, in absence of treatment, it eventually results in death. Therefore, the dysregulation of inflammatory immune responses, by any mean can improve the health of the patients. It was evident that most patients who were suffering from severe SARS-CoV-2, exhibit a high level of pro-inflammatory cytokines, including interferon (IFN)-α, and interleukin (IL)-1β. In these circumstances, an immunotherapeutic strategy will be effective for the suppression of cytokine storms and will prevent any respiratory failure in the patients.