Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Kaialy, Waseem; Al Shafiee, Maen

dc.contributor.author	Kaialy, Waseem
dc.contributor.author	Al Shafiee, Maen
dc.date.accessioned	2016-03-15T10:26:30Z	en
dc.date.available	2016-03-15T10:26:30Z	en
dc.date.issued	2015-12-08
dc.identifier.citation	Kaialy, W. & Al Shafiee, M. (2016) Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges, Advances in Colloid and Interface Science, 228, pp.71-79	en
dc.identifier.issn	00018686
dc.identifier.doi	10.1016/j.cis.2015.11.010
dc.identifier.uri	http://hdl.handle.net/2436/601336
dc.description	This is an accepted manuscript of an article published by Elsevier in Advances in Colloid and Interface Science on 15/01/2016, available online: https://doi.org/10.1016/j.cis.2015.11.010 The accepted version of the publication may differ from the final published version.	en
dc.description.abstract	The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.
dc.language.iso	en
dc.publisher	Elsevier BV	en
dc.relation.url	http://linkinghub.elsevier.com/retrieve/pii/S0001868615002183
dc.subject	Bioavailability	en
dc.subject	Dissolution rate	en
dc.subject	Nanoparticle engineering	en
dc.subject	Nanosizing	en
dc.subject	Poorly soluble APIs	en
dc.subject	Solubility	en
dc.title	Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges	en
dc.type	Journal article	en
dc.identifier.journal	Advances in Colloid and Interface Science	en
dc.source.volume	228
dc.source.beginpage	71
dc.source.endpage	79
refterms.dateFOA	2018-02-01T00:00:00Z
html.description.abstract	The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.	en